Human papillomavirus infections during pregnancy and adverse pregnancy outcomes: a Scandinavian prospective mother-child cohort study
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Le résumé fourni par la source
BACKGROUND: Human papillomaviruses are common in the urogenital tract amongst women of childbearing age. A few studies indicate a possible association between human papillomavirus infections in pregnancy and adverse pregnancy outcomes whilst other studies find no such association. We aimed to investigate the association between human papillomavirus infections during pregnancy and adverse pregnancy outcomes linked to placental dysfunction, including hypertensive disorders of pregnancy, gestational diabetes mellitus and newborns small for gestational age. MATERIALS AND METHODS: Pregnant women from the general population in Norway and Sweden were enrolled at the time of routine mid-gestational ultrasound examination. Urine samples collected at mid-gestation in 950 and at delivery in 753 participants, were analyzed for 28 human papillomavirus genotypes, including 12 high-risk genotypes. Participants completed electronic questionnaires at enrollment and medical records were reviewed for background characteristics and for the following adverse pregnancy outcomes: hypertensive disorders of pregnancy including gestational hypertension, preeclampsia, superimposed preeclampsia, eclampsia and Hemolysis Elevated Liver enzymes and Low Platelets (HELLP) syndrome, gestational diabetes mellitus, and newborns small for gestational age. Associations between adverse pregnancy outcomes and (a) any human papillomavirus, high-risk human papillomavirus and human papillomavirus genotype 16 infection at mid-gestation, (b) multiple genotype infections at mid-gestation, and (c) persisting infections during pregnancy were assessed with univariable and multivariable logistic regression models. Missing covariates were imputed using multiple imputation. RESULTS: At mid-gestation, 40% (377/950) of women were positive for any of the 28 genotypes, 24% (231/950) for high-risk genotypes and human papillomavirus 16 was found in 6% (59/950) of the women. Hypertensive disorders of pregnancy was observed in 9% (83/950), gestational diabetes mellitus in 4% (40/950) and newborns small for gestational age in 7% (67/950). Human papillomavirus infection with any genotype, high-risk or human papillomavirus genotype 16 at mid-gestation was not associated with adverse pregnancy outcomes. No associations were found for multiple genotype infections at mid-gestation or persisting infections. CONCLUSION: In a general population of pregnant women, we found no evidence of human papillomavirus infections during pregnancy being associated with hypertensive disorders of pregnancy, gestational diabetes mellitus, or newborns small for gestational age. TRIAL REGISTRATION: Trial registration The study is registered at ClincialTrials.gov; NCT02449850 on May 19th, 2015.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Human papillomavirus infections during pregnancy and adverse pregnancy outcomes: a Scandinavian prospective mother-child cohort study
- Date Crossref
- 19/11/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Oslo pays non établi dans la noticeUniversité ou école supérieure
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Østfold Hospital Trust Department of Obstetrics and Gynecology pays non établi dans la noticeÉtablissement de santé
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Oslo University Hospital Division of Obstetrics and Gynaecology pays non établi dans la noticeÉtablissement de santé
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University of Gothenburg pays non établi dans la noticeUniversité ou école supérieure
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Norwegian Institute of Public Health Department of Chemical Toxicology pays non établi dans la noticeOrganisme public
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Karolinska University Hospital Astrid Lindgren Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Karolinska Institutet Department of Women's and Children's Health pays non établi dans la noticeUniversité ou école supérieure
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Norwegian University of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Gothenburg University Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Centre for Laboratory Medicine Genetic Unit pays non établi dans la noticeStructure de recherche
University of Oslo, Department of Obstetrics and Gynecology — Østfold Hospital Trust et Division of Obstetrics and Gynaecology — Oslo University Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.