Improving the Theranostic Potential of Magnetic Nanoparticles by Coating with Natural Rubber Latex for Ultrasound, Photoacoustic Imaging, and Magnetic Hyperthermia: An In Vitro Study

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BACKGROUND/OBJECTIVES: Magnetic nanoparticles (MNPs) have gained attention in theranostics for their ability to combine diagnostic imaging and therapeutic capabilities in a single platform, enhancing targeted treatment and monitoring. Surface coatings are essential for stabilizing MNPs, improving biocompatibility, and preventing oxidation that could compromise their functionality. Natural rubber latex (NRL) offers a promising coating alternative due to its biocompatibility and stability-enhancing properties. While NRL-coated MNPs have shown potential in applications such as magnetic resonance imaging, their effectiveness in theranostics, particularly magnetic hyperthermia (MH) and photoacoustic imaging (PAI), remains underexplored. METHODS: In this study, iron oxide nanoparticles were synthesized via coprecipitation, using NRL as the coating agent. The samples were labeled by NRL amount used during synthesis: NRL-100 for 100 μL and NRL-400 for 400 μL. RESULTS: . Building on these findings, we evaluated the performance of these nanoparticles in biomedical applications, including magnetomotive ultrasound (MMUS), PAI, and MH. NRL-100 and NRL-400 samples showed greater displacements and higher contrast in MMUS than uncoated samples (5, 8, and 9 µm) at 0.5 wt%. In addition, NRL-coated samples demonstrated an improved signal-to-noise ratio (SNR) in PAI. SNR values were 24.72 (0.51), 31.44 (0.44), and 33.81 (0.46) dB for the phantoms containing uncoated MNPs, NRL-100, and NRL-400, respectively. Calorimetric measurements for MH confirmed the potential of NRL-coated MNPs as efficient heat-generating agents, showing values of 43 and 40 W/g for NRL-100 and NRL-400, respectively. CONCLUSIONS: Overall, NRL-coated MNPs showed great promise as contrast agents in MMUS and PAI imaging, as well as in MH applications.

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