The therapeutic role of exercise training during menopause for reducing vascular disease
Rattachement africain : au, gb, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk. During menopause, reductions in nitric oxide (NO) bioavailability, endothelial dysfunction, increases in systemic inflammation, oxidative stress, and impaired vascular remodelling may contribute towards an accelerated decline in the function of cerebral and peripheral vascular systems. Historically, hormone therapy (HT) has been used as a means of managing vascular disease risk and reducing menopause-associated vasomotor symptoms such as hot flushes, though some studies suggest regular exercise has the potential to be a promising alternative. Regular aerobic exercise during early postmenopause may slow vascular decline by improving NO and oestradiol bioavailability, promoting positive vascular remodelling and lowering systemic inflammation. However, exercise-mediated improvements in markers of vascular function are not consistently observed in oestradiol-deficient postmenopausal women. Emerging evidence suggests that due to the greater oestradiol bioavailability during early postmenopause, vascular adaptations to exercise may be enhanced during this stage, as opposed to late postmenopause. Subsequently it may be important to begin regular exercise in the years preceding and immediately following the final menstrual period to slow the progression of vascular disease risk during perimenopause and beyond. The present review will provide a summary of our current understanding of how vascular function is affected during menopause and the role of regular aerobic and resistance exercise training in managing vascular disease risk.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The therapeutic role of exercise training during menopause for reducing vascular disease
- Date Crossref
- 19/11/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Queensland pays non établi dans la noticeUniversité ou école supérieure
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University of Exeter Public Health and Sport Sciences pays non établi dans la noticeUniversité ou école supérieure
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Geriatric Research Education and Clinical Center Eastern Colorado Health Care System pays non établi dans la noticeÉtablissement de santé
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VA Eastern Colorado Health Care System pays non établi dans la noticeÉtablissement de santé
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University of Colorado Anschutz Division of Geriatric Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Human Movement and Nutrition Sciences University of Queensland Brisbane Australia Physiology and Ultrasound Laboratory in Science and Exercise (PULSE) pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health and Life Sciences Public Health and Sport Sciences pays non établi dans la noticeUniversité ou école supérieure
The University of Queensland, Public Health and Sport Sciences — University of Exeter et Eastern Colorado Health Care System — Geriatric Research Education and Clinical Center, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.