Evaluation of cerebral perfusion heterogeneity by the electrical impedance tomography

Résumé fourni par la source

Purpose: The purpose of this study was to evaluate the ability of global inhomogeneity index (GI) and left-right asymmetry index (AI) based on electrical impedance tomography (EIT) to be used in assessing cerebral perfusion heterogeneity. The diagnostic value of these two indices in identifying abnormalities in the degree of cerebral perfusion heterogeneity was also explored. Methods: In this study, Transcranial Doppler (TCD) was used as a control, and unilateral carotid artery was compressed to change the degree of heterogeneity of cerebral perfusion in 15 healthy volunteers. The control group consisted of an additional 15 volunteers without any intervention. EIT perfusion images were obtained by calculating the impedance difference between at the beginning and end of cerebral vasodilation. Subsequently, GI and AI were calculated based on the pixel values of intracranial regions. Results: The GI and AI values in the non-carotid artery compression (NCAC) group were significantly lower than those in the unilateral carotid artery compression (UCAC) group (P < 0.001), whereas there was no significant difference between the left carotid artery compression (LCAC) and right carotid artery compression (RCAC) groups. ROC analysis showed that the area under the curve (AUC), specificity and sensitivity of GI in distinguishing between NCAC and UCAC were 0.94, 0.90 and 0.87, respectively. The AUC, specificity and sensitivity of AI in distinguishing between NCAC and UCAC were 0.86, 0.87 and 0.73, respectively. Conclusion: The results demonstrated that the GI and AI effectively quantify the distribution of intracranial perfusion, demonstrating excellent validity and interindividual comparability, and the ability to detect abnormal cerebral perfusion heterogeneity.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.