Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study
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Le résumé fourni par la source
Impaired pulmonary diffusing capacity for carbon monoxide (DLCO) following COVID-19 has been consistently reported among individuals recovering from severe-critical infection. However, most long COVID cases follow non-severe COVID-19. We assessed DLCO among individuals with long COVID recovering from mild to moderate acute illness. A cross-sectional study of adults with long COVID, assessed at a COVID recovery clinic > 3 months following the onset of acute infection, during 2020-2021. Participants subjectively ranked their dyspnea severity based on its impact on their daily living and underwent comprehensive pulmonary function testing (PFT). Clinical correlates for impaired DLCO (defined as < 80%) were assessed using multivariable logistic regression models. A total of 458 individuals, their mean age 45 (SD 16) and 246 (54%) of whom are women, were evaluated at an average of ~ 4 months following acute COVID-19. The most frequent PFT impairment was reduced DLCO, identified among 67 (17%) of the cohort. Clinical correlates of impaired DLCO included women (odds ration [OR] 3.64, 95% confidence interval [CI] 1.78-7.45, p < 0.001), cigarette smoking (OR 2.25, 95% CI 1.14-4.43, p = 0.019), and moderate-severe dyspnea (OR 2.77, 95% CI 1.39-5.50, p = 0.004). BMI inversely correlated with DLCO (OR 0.90, 95% CI 0.85-0.96 per 1 unit, p = 0.002). Impaired DLCO was not uncommon among individuals recovering from mild to moderate COVID-19. Women are at a greater risk, and subjective dyspnea correlated with impaired DLCO. Clinicians can rely on self-reported significant dyspnea to guide further assessment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study
- Date Crossref
- 05/11/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tel Aviv University pays non établi dans la noticeUniversité ou école supérieure
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Sheba Medical Center Infectious Diseases Unit pays non établi dans la noticeÉtablissement de santé
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Rabin Medical Center Department of Internal Medicine E pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Research Authority pays non établi dans la noticeOrganisme public
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Sagol School of Neuroscience Functional MRI Center pays non établi dans la noticeUniversité ou école supérieure
Tel Aviv University, Infectious Diseases Unit — Sheba Medical Center et Department of Internal Medicine E — Rabin Medical Center, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.