Association of Postdonation Kidney Function and Risk of CKD in Living Kidney Donors at the Civil Hospital of Guadalajara, Mexico

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Background: In Mexico, according to figures from the National Transplant Center Registry, more than 90% of transplants are from living donors.This makes it difficult to estimate the risk attributable to donation. The outcome of donors in our country is unknown, in terms of risk of progression to CKD and comorbidities. In previous studies, some of which do not confer a higher risk, mainly in the first-world population. Methods: Cross-sectional cohort study without retrospective intervention, Unicentro, of kidney donor patients from the program of the Civil Hospital of Guadalajara. In the period from January 2019 to December 2022, at the 5-year follow-up. Objective: Association of post-donation renal function from the year of donation and risk of chronic kidney disease with a 30% loss of GFR, renal replacement therapy. Results: found with an average age of 39 years in total. The 93.2% (124) of donors do not have social or private security. The eGFR before donation was 102.21 ml/min/1.73 m2. (DE +/ 7.65ml/min/1.73m2) . Only 11.1% achieved renal MAKE. + The estimated glomerular filtration rate was compared with the CKD-EPI formula with serum creatinine, baseline eGFR with a mean of 102.21 ml/min/1.73m2 SD +/- 7.65 ml/min/1.73m2 and at follow-up at the fifth year with a mean 80.5ml/min/1.73m2 SD +/- 9.78 ml/min/1.73m2 with a decrease in eGFR with a non-significant value of p=0.8438. + Kidney donors were analyzed, comparing their baseline pre-kidney donation BMI (26.4 kg/m2 SD +/- 1.78 kg/m2), at follow-up BMI 27.3 kg/m2 SD +/- 9.3 kg/m2 with a significant difference of p=0.0162Conclusion Conclusion: In this study, we observed that although there was a significant difference in renal function at 5 years post-transplant,, but 11.2% of our population had it MAKE RENAL. .

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