Association between Median Liver Stiffness and Proteinuria among US Adults: NHANES, 2017-2020

Le résumé fourni par la source

Background: Liver stiffness is linked to CKD and proteinuria. There is limited national-scale evidence on the impact of gender on this relationship. This study explores if gender influences the risk of proteinuria associated with liver stiffness. Methods: A national study involving 6,525 adults, using NHANES 2017-2020 ,investigated the relationship between median liver stiffness and ACR. Liver stiffness was categorized into four fibrosis scores with cut-off points at 2-7, 7-11, 11-19, and ≥19 kPa. Three linear regression (LR) models were utilized,considering each gender subgroups [Table 1]. Results: Median liver stiffness was categorized into four fibrosis scores (F1 through F4) among male and female participants. For males, the majority were classified as F1, with 2,620 individuals (84.57%). This was followed by 355 individuals (11.46%) with F2, 99 individuals (3.20%) with F3, and 24 individuals (0.77%) with F4. Similarly, most females were classified as F1, with 3,019 individuals (88.15%). This was followed by 296 individuals (8.64%) with F2, 91 individuals (2.66%) with F3, and 19 individuals (0.55%) with F4. In the final adjusted LR model, the ACR increased significantly for each unit increase in median liver stiffness, by 0.76 (95% CI: 0.13-1.40) in the total group and by 1.74 (95% CI: 0.70-2.79) in female [Table 1]. Conclusion: A significant positive correlation between ACR and median liver stiffness, influenced by gender, was found among US adults. This suggests that monitoring kidney function and proteinuria, especially in women with a history of liver disease, is crucial for the early detection of kidney injury. - Model 1 Model 2 Model 3 β-Coefficients(95%CI) P-value β-Coefficients(95%CI) P-value β-Coefficients(95%CI) P-value Total 1.48 (1.06, 1.91) <0.001 0.99 (0.36, 1.63) <0.002 0.76 (0.13, 1.40) <0.018 Male 1.54 (0.97, 2.11) <0.001 0.51 (-0.29, 1.31) 0.212 0.28 (-0.52, 1.08) 0.494 Female 1.66 (1.04, 2.29) <0.001 1.92 (0.87, 2.96) <0.001 1.74 (0.70, 2.79) 0.001 Fig 1: Table of correlation analysis between Median Liver Stiffness and Albumin Creatinine Ratio (ACR) using three different logistic regression models. The first model included only Median Liver Stiffness, the second model added age, race, smoking, and drinking, and the third model further included dyslipidemia, hypertension, diabetes, coronary artery disease, congestive heart failure, and stroke.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.