Peripheral Dopaminergic Agonist Activity of Aminoethylindolones and Related Compounds

Le résumé fourni par la source

Many different chemical structures have demonstrated preferential agonist activity at peripheral prejunctional DA 2 as opposed to postjunctional DA 1 receptors (for a good general review of the structure activity relationships of dopaminergic agonists see Ref. 1 ). Among the diverse classes ( Fig. 1 ) of agents that show selectivity for the DA 2 receptor are alkylated derivatives of dopa-mine, such as di-n-propyldopamine and N -propyl- N -butyldopamine; cyclized dopamine derivatives, such as 2-aminotetrahydronaphthalenes and aporphines (See Chaps. 3 and 4 ); ergot alkaloids, such as bromocryptine; simplified fragments of the ergots such as LY141865 ( 2 ; see Chap. 9 ); benzazepines, such as SK&F 85174 ( 3 , 4 ; see Chap. 7 ); as well as numerous other less well-known classes ( 1 ).

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.