Efficacy of Bile Acid Sequestrants in the Treatment of Bile Acid Diarrhea: A Meta‐Analysis of Randomized Controlled Trials
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Le résumé fourni par la source
Bile acid sequestrants (BASs) have often been used for bile acid diarrhea (BAD) but carry a high risk of adverse events. New generations of BASs show promising results; however, their efficacy remains unclear. This systematic review and meta-analysis was conducted using PubMed, Cochrane, and Embase to assess randomized controlled trials (RCTs) published up to November 2023 to retrieve studies that measured the parameters before and after the administration of BASs. The outcomes assessed were cessation or improvement in diarrhea, fecal consistency, abdominal cramping, frequency of diarrhea, and adverse events. Risk ratios (RRs) and mean differences with 95% confidence intervals (CIs) were pooled using a random-effects model. Statistical analyses were conducted using RStudio version 4.1.2. The protocol was prospectively registered with PROSPERO (CRD42023445444). Seven RCTs with a total of 311 patients were included, of which 168 (54%) were randomized to BASs. Among BAS-treated patients, 101 (60.1%) received colesevelam, 40 (23.8%) received chenodeoxycholate, 18 (10.7%) received cholestyramine, and 9 (5.3%) received colestid. BASs were associated with a significant improvement in the cessation of diarrhea (RR 3.27; 95% CI 2.08 to 5.15; P ≤ .05) and liquid stool to normal fecal consistency (RR 2.69; 95% CI 1.56 to 4.65; P ≤ .05), as well as an increase in abdominal cramps (RR 5.27; 95% CI 1.21 to 22.93; P ≤ .05). There were no differences in urgency, adverse events, or nausea between groups. These findings indicate that BASs are effective in the treatment of BAD, as indicated by the improvement or cessation of diarrhea episodes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Efficacy of Bile Acid Sequestrants in the Treatment of Bile Acid Diarrhea: A Meta‐Analysis of Randomized Controlled Trials
- Date Crossref
- 21/10/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Metropolitana de Santos pays non établi dans la noticeUniversité ou école supérieure
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Cardiff University pays non établi dans la noticeUniversité ou école supérieure
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Faculdade Redentor pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal Fluminense pays non établi dans la noticeUniversité ou école supérieure
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Department of Medicine Metropolitan University of Santos São Paulo Brazil pays non établi dans la noticeUniversité ou école supérieure
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Federal University of the Southern Border Passo Fundo Brazil pays non établi dans la noticeUniversité ou école supérieure
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Redentor University Center Rio de Janeiro Brazil pays non établi dans la noticeUniversité ou école supérieure
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Department of Medicine Federal University of Fluminense Rio de Janeiro Brazil Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Metropolitan University of Santos Santos São Paulo Brazil pays non établi dans la noticeUniversité ou école supérieure
Universidade Metropolitana de Santos, Cardiff University et Faculdade Redentor, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.