A gut-focused perinatal dietary intervention is associated with lower alpha diversity of the infant gut microbiota: results from a randomised controlled trial
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Le résumé fourni par la source
Objectives: In experimental models, the prenatal diet influences gut microbiota composition in mothers and offspring; however, it is unclear whether this occurs in humans. We investigated the effects of a gut-focused perinatal dietary intervention on maternal and infant gut microbiota composition four weeks after birth.Methods: This randomised controlled trial randomised pregnant women to receive dietary advice as part of standard care, or additionally receive a dietary intervention focused on the Australian Dietary Guidelines and increasing prebiotic and probiotic/fermented food intakes (ACTRN12616000936426). Study assessments occurred from gestation week 26 (baseline) to four weeks postpartum (follow-up). Faecal samples, collected at baseline for mothers, and follow-up for mothers and infants, underwent 16SrRNA sequencing. The primary outcome was a between-group mean difference in infant faecal Shannon index. Secondary outcomes included between-group differences in other microbiota measures, including maternal change from baseline CLR-transformed Prevotella abundance.Results: Forty-four women and 45 infants completed the study. The mean Shannon index of infants in the intervention group was −0.35 (95% CI: −0.64, −0.06, SD: 0.52) units lower than control group infants, corresponding to a medium effect size (Cohen’s D: −0.74, 95% CI: −1.34, −0.13). The findings were similar using other metrics of α-diversity. There were no between-group differences in β-diversity, nor any differentially abundant taxa in infants. The intervention increased abundances of the genus Prevotella in mothers compared to controls.Discussion: This gut-focused perinatal dietary intervention was associated with differences in the maternal and infant gut microbiota composition. Larger studies are required to replicate and extend these findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A gut-focused perinatal dietary intervention is associated with lower alpha diversity of the infant gut microbiota: results from a randomised controlled trial
- Date Crossref
- 18/10/2024
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Royal Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Deakin University IMPACT (The Institute for Mental and Physical Health and Clinical Translation) pays non établi dans la noticeUniversité ou école supérieure
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Murdoch Children's Research Institute pays non établi dans la noticeOrganisation à but non lucratif
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University College Cork APC Microbiome Ireland pays non établi dans la noticeUniversité ou école supérieure
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Infant pays non établi dans la noticeStructure de recherche
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APC Microbiome Institute pays non établi dans la noticeStructure de recherche
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The University of Melbourne The Florey Institute of Neuroscience and Mental Health pays non établi dans la noticeUniversité ou école supérieure
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Florey Institute of Neuroscience and Mental Health pays non établi dans la noticeStructure de recherche
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Norwegian Institute of Public Health Cluster of Reviews and Health Technology Assessments pays non établi dans la noticeOrganisme public
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Barwon Health pays non établi dans la noticeÉtablissement de santé
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James Cook University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health pays non établi dans la noticeUniversité ou école supérieure
Royal Children's Hospital, IMPACT (The Institute for Mental and Physical Health and Clinical Translation) — Deakin University et Murdoch Children's Research Institute, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.