P22.11.A POOR SELF-REPORTED PHYSICAL FUNCTIONING IN GLIOMA PATIENTS ACROSS THE DISEASE TRAJECTORY

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Abstract BACKGROUND Few studies have investigated physical functioning at multiple moments in the disease trajectory of glioma patients, nor have the correlates of physical functioning been determined. We therefore analyzed physical functioning in a large sample of glioma patients both at time of diagnosis and after primary treatment. MATERIAL AND METHODS In this retrospective study (patients were diagnosed between 2007-2023), the self-reported physical functioning subscale of the 36-Item Short Form Health Survey (SF-36) was used. Each patient was matched with two general population controls based on age, sex, and educational level. First, we compared physical functioning at time of diagnosis and after treatment with matched controls. Next, we determined correlates of patients’ physical functioning at both time points, namely age, sex, educational level, tumor histology, location, lateralization and grade, type of treatment, presence of epilepsy, usage of dexamethasone, Karnofsky Performance Status (KPS) and the National Institutes of Health Stroke Scale (NIHSS). Finally, in patients with assessments both at diagnosis and after treatment, we determined change in physical functioning over time. RESULTS We included 260 glioma patients at time of diagnosis and 109 glioma patients after treatment. Compared to controls, physical functioning of patients was significantly lower at the time of diagnosis (p = 0.022) and after treatment (p = 0.002). At both time points, poorer physical functioning was associated with having a tumor grade III, and KPS lower than 80. Moreover, at diagnosis only, poorer physical functioning correlated with lower educational level and right-sided tumor lateralization. Within the 77 glioma patients with data available at both time points, there was a large individual variability in change over time (28% increased; 40% decreased), but there was no significant change at the group level (p = 0.300). CONCLUSION Physical functioning is poor in glioma patients, regardless of phase of the disease. The main correlates of poor physical functioning are tumor and patient characteristics, such as KPS, tumor grade, educational level, tumor lateralization. Interestingly, neurological deficits were not related to physical functioning. Interventions aimed at improving physical functioning in glioma patients should be explored.

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