Differing effectiveness of transcranial random noise stimulation and transcranial direct current stimulation for enhancing working memory in healthy individuals: a randomized controlled trial
Rattachement africain : jp, hk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (DLPFC) is a promising technique for enhancing working memory (WM) performance in healthy and psychiatric populations. However, limited information is available about the effectiveness of transcranial random noise stimulation (tRNS) applied to the left DLPFC on WM. This study investigated the effectiveness of tRNS on WM compared with that of tDCS, which has established functional evidence. METHODS: This randomized, double-blind, sham-controlled trial enrolled 120 healthy right-handed adults who were randomly allocated to four stimulation groups: tRNS + direct current (DC) offset, tRNS, tDCS, or sham. Each stimulus was placed over the left DLPFC and had a current intensity of 2 mA applied for 20 min during the dual n-back task. The dual n-back task was repeated thrice: pre-stimulation, during stimulation, and post-stimulation. The d-prime scores, and response times were calculated as the main outcome measures. A linear mixed model was created to identify the main effects and interactions between the groups and times, with the group and time as fixed effects, and baseline performance and the subject as a covariate and random effect, respectively. The relationships between the benefit of each stimulus and baseline WM performance were also examined. RESULTS: For the d-prime score during stimulation, the tRNS group significantly performed better than the sham group at online assessment (β = 0.310, p = 0.001). In the relationships between the benefit of each stimulus and baseline WM performance, the tRNS group had significantly larger negative line slopes than the sham group for the d-prime score (β = -0.233, p = 0.038). CONCLUSIONS: tRNS applied to the left DLPFC significantly improved WM performance and generated greater benefits for healthy individuals with lower WM performance. These findings highlight the potential utility of tRNS for enhancing WM performance in individuals with lower WM performance and contribute evidence for clinical application to patients with cognitive decline. TRIAL REGISTRATION: This study was registered in the University Hospital Medical Information Network Clinical Trial Registry in Japan (UMIN000047365) on April 1, 2022; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054021 .
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Differing effectiveness of transcranial random noise stimulation and transcranial direct current stimulation for enhancing working memory in healthy individuals: a randomized controlled trial
- Date Crossref
- 14/10/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sapporo University pays non établi dans la noticeUniversité ou école supérieure
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Hokkaido University Institute of Health Science Innovation for Medical Care pays non établi dans la noticeUniversité ou école supérieure
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Fukuoka International University pays non établi dans la noticeUniversité ou école supérieure
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International University of Health and Welfare pays non établi dans la noticeUniversité ou école supérieure
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Hokkaido University Hospital pays non établi dans la noticeÉtablissement de santé
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Sapporo Medical University Department of Physical Therapy pays non établi dans la noticeUniversité ou école supérieure
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Health Sciences University of Hokkaido Department of Rehabilitation Sciences pays non établi dans la noticeUniversité ou école supérieure
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Hong Kong Polytechnic University Department of Rehabilitation Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health Sciences Department of Rehabilitation Science pays non établi dans la noticeUniversité ou école supérieure
Sapporo University, Institute of Health Science Innovation for Medical Care — Hokkaido University et Fukuoka International University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.