Readily constructed squaraine J-aggregates with an 86.0 % photothermal conversion efficiency for photothermal therapy
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Le résumé fourni par la source
The development of photothermal agents with high photothermal conversion efficiency (PCE) and long absorption wavelengths is crucial for safe and effective anti-cancer treatment. However, achieving these advantages often requires precise molecular design and complex synthetic procedures. In this study, we present a simple, precise, and effective method for fabricating photothermal agents with high PCE using long wavelength excitation. This approach involves linking two electron-donating components, diphenylamine (DPA), and an electron-withdrawing squaraine (SQ), via a π-bridge thiophene (T). The resulting D-π-A-π-D structure leads to a red-shifted absorption band. Within the DTS structure, DPA functions as a molecular rotor, T serves as a coplanar backbone, and SQ promotes J aggregation. When DTS nanoparticles (NPs) are fabricated using an amphiphilic nano-carrier, the maximum absorption wavelength shifts from 701 to 803 nm. This shift is accompanied by reduced fluorescence and an exceptionally high PCE of 86.0 %. Both in vitro and in vivo assessments confirm that DTS NPs exhibit strong potential for photothermal antitumor therapy. Overall, this strategy offers a valuable framework for designing photothermal agents with clinical applications in mind, offering a simpler and more efficient approach to achieving high PCE and long absorption wavelengths. • Squaraine-based D-π-A-π-D type photothermal agents (DTS) were synthesized. • The fabricated DTS nanoparticles exhibited an impressive PCE of 86.0 % under an 808 nm laser. • The theoretical calculation results revealed the mechanism of its ultra-high PCE. • The DTS nanoparticles demonstrated remarkable stability and efficient antitumor performance both in vitro and in vivo.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Readily constructed squaraine J-aggregates with an 86.0 % photothermal conversion efficiency for photothermal therapy
- Date Crossref
- 01/01/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangdong Medical College pays non établi dans la noticeUniversité ou école supérieure
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Southern University of Science and Technology Shenzhen People's Hospital pays non établi dans la noticeUniversité ou école supérieure
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Education Department of Fujian Province pays non établi dans la noticeOrganisme public
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National University of Singapore Department of Chemical and Biomolecular Engineering pays non établi dans la noticeUniversité ou école supérieure
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Longgang Central Hospital Department of Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Institute of Biomedical Engineering pays non établi dans la noticeStructure de recherche
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School of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Fujian Bote Biotechnology Co. Ltd pays non établi dans la noticeEntreprise
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Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
Guangdong Medical College, Shenzhen People's Hospital — Southern University of Science and Technology et Education Department of Fujian Province, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.