Choosing the optimal concentration of dextran sulfate sodium for reproducing chemically induced colitis in rabbits
Rattachement africain : ru. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background. Due to the fact that inflammatory bowel diseases (IBD) are widespread among the population, the development of new drugs for the treatment of IBD is a public health priority. Preclinical drug testing is inextricably linked with the modeling of IBD in laboratory animals. This study purpose was to develop a model of chemically induced colitis in rabbits. Methods. The study was performed on male rabbits of the “Soviet Chinchilla” breed. Colitis was simulated by oral administration of dextran sulfate sodium (DSS) in a concentration of 0.1% to 2% solution for five consecutive days. Euthanasia of laboratory animals was carried out on the seventh day, after the end of taking the DSS solution. A histological examination of the intestine was performed. Results. It was found that using 0.1% DSS solution allows to obtain a model of mild erosive colitis. The use of 0.5% DSS solution gave the intermediate severity of erosive ulcerative colitis. DSS concentration of more than 1% led to the development of severe ulcerative colitis in rabbits and the death rate of 71.4% among them. Conclusion. The obtained results indicate that the use of 0.5% DSS solution makes it possible to create a model of erosive ulcerative colitis in rabbits suitable for studying human IBD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Choosing the optimal concentration of dextran sulfate sodium for reproducing chemically induced colitis in rabbits
- Date Crossref
- 17/01/2024
- Éditeur
- LLC Global Media Technology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Russian Medical Academy of Continuous Professional Education pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Health of the Russian Federation pays non établi dans la noticeOrganisme public
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Saint-Petersburg Research Institute of Phthisiopulmonology pays non établi dans la noticeStructure de recherche
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Moscow Research and Clinical Center for Neuropsychiatry pays non établi dans la noticeÉtablissement de santé
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Pirogov Russian National Research Medical University Moscow Research and Clinical Center for TB Control Moscow Healthcare Department pays non établi dans la noticeUniversité ou école supérieure
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Moscow Research and Clinical Center for TB Control Moscow Healthcare Department pays non établi dans la noticeÉtablissement de santé
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Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation pays non établi dans la noticeStructure de recherche
Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation et Saint-Petersburg Research Institute of Phthisiopulmonology, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.