Insulin resistance and insulin secretory defect among Bangalee PCOS women: a case-control study
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Le résumé fourni par la source
Insulin resistance (IR) is a well-recognized covariate of Polycystic Ovarian Syndrome (PCOS) with varying burden and risk factors among populations. The relationship of insulin secretory defect or ISD with PCOS is less understood. The presence of IR and ISD as well as their covariates have been explored in the present case-control study among young adult to early middle-aged, normal weight to obese, Bangalee women with PCOS. A number of 158 PCOS [age 23 (15-34) years, Median (Range)] and 126 Non-PCOS [24 (19-34) years] females were recruited purposively with PCOS diagnosed following Modified Rotterdam Criteria 2003. Hormones were measured by CLIA method and lower abdominal ultrasonography was done by trained personnel. IR and ISD were assessed by homeostasis model assessment with 75th percentile values of HOMA-IR (2.4) and HOMA%B (143) in Non-PCOS group considered as the cut-off values. Hyperandrogenism (HA) was measured by calculating Fasting Androgen Index (FAI). HOMA-IR was high among 52% of PCOS and 28% of Non-PCOS women. Body Mass Index (BMI) and HA were independently associated covariates of IR (p < 0.001). HOMA%B was compromised among 48% of PCOS subjects and the deficiency showed independent association (p < 0.001) with 2 h glycemia on OGTT in Non-PCOS and HA in PCOS groups. The data suggest insulin resistance as a major risk factor for PCOS among Bangalee women with obesity and hyperandrogenemia as its major covariates. The findings also indicate that presence of impaired insulin secretion is a major determinant of hyperglycemia and, consequently, of higher T2DM risk among young women in this population.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Insulin resistance and insulin secretory defect among Bangalee PCOS women: a case-control study
- Date Crossref
- 30/09/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Dhaka Department of Biochemistry & Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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Bangladesh Medical University pays non établi dans la noticeUniversité ou école supérieure
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Bangabandhu Sheikh Mujib Medical University (BSMMU) Department of Reproductive Endocrinology and Infertility pays non établi dans la noticeUniversité ou école supérieure
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Department of Endocrinology & Metabolism (BSMMU) pays non établi dans la noticeInstitution
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Pothikrit Institute of Health Studies (PIHS) pays non établi dans la noticeStructure de recherche
Department of Biochemistry & Molecular Biology — University of Dhaka, Bangladesh Medical University et Department of Reproductive Endocrinology and Infertility — Bangabandhu Sheikh Mujib Medical University (BSMMU), avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.