Tissue-Engineered Three-Dimensional Platforms for Disease Modeling and Therapeutic Development

Le résumé fourni par la source

that affect numerous tissues and organs, including cardiovascular, gastrointestinal, bone marrow, neural, reproductive, and pulmonary systems. We discuss current technologies for engineered tissue models, highlighting the advantages, limitations, and important considerations for modeling tissues and diseases. Lastly, we discuss future advancements necessary to enhance the reliability of 3D models of tissue development and disease. Impact Statement In this review, we describe recent progress in the development and application of three-dimensional (3D) tissue-engineered models of disease. We discuss common approaches to create 3D models from somatic and stem and progenitor cells using spheroids, organoids, biomaterials, and microphysiological systems. In addition, we describe the application of such systems to model various disorders, discover mechanisms of progression, and identify new therapeutics to combat disease, which will be useful for subsequent research and clinical translation.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.