Gut colonization of Enterococcus species is associated with COVID-19 disease in Uganda
Rattachement africain : us, Ouganda. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Infection with the COVID-19-causing pathogen SARS-CoV-2 is associated with disruption in the human gut microbiome. The gut microbiome enables protection against diverse pathogens and exhibits dysbiosis during infectious and autoimmune disease. Studies based in the United States and China have found that severe COVID-19 cases have altered gut microbiome composition when compared to mild COVID-19 cases. We present the first study to investigate the gut microbiome composition of COVID-19 cases in a population from Sub-Saharan Africa. Given the impact of geography and cultural traditions on microbiome composition, it is important to investigate the microbiome globally and not draw broad conclusions from homogenous populations. Results We used stool samples in a Ugandan biobank collected from COVID-19 cases during 2020-2022. We profiled the gut microbiomes of 114 symptomatic individuals who tested positive for SARS-CoV-2 along with 76 household contacts who did not present any symptoms of COVID-19. The inclusion of healthy controls enables us to generate hypotheses about bacterial strains potentially related to susceptibility to COVID-19 disease, which is highly heterogeneous. Comparison of the COVID-19 patients and their household contacts revealed decreased alpha diversity and blooms of Enterococcus and Eggerthella in COVID-19 cases. Conclusions Our study finds that the microbiome of COVID-19 individuals is more likely to be disrupted, as indicated by decreased diversity and increased pathobiont levels. This is either a consequence of the disease or may indicate that certain microbiome states increase susceptibility to COVID-19 disease. Our findings enable comparison with cohorts previously published in the Global North, as well as support new hypotheses about the interaction between the gut microbiome and SARS-CoV-2 infection.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Gut colonization of <i>Enterococcus</i> species is associated with COVID-19 disease in Uganda
- Date Crossref
- 30/09/2024
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of California Biophysics PhD program pays non établi dans la noticeUniversité ou école supérieure
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Makerere University Makerere University, Ouganda (code pays fourni par la source)Université ou école supérieure
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Berkeley College pays non établi dans la noticeUniversité ou école supérieure
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MRC/UVRI & LSHTM Uganda Research Unit Ouganda (code pays fourni par la source)Structure de recherche
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Uganda Virus Research Institute Ouganda (code pays fourni par la source)Structure de recherche
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School of Public Health Division of Infectious Diseases and Vaccinology pays non établi dans la noticeUniversité ou école supérieure
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School of Biomedical Sciences Department of Immunology and Molecular Biology Makerere, Ouganda (pays nommé en fin d’affiliation)Université ou école supérieure
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Integrated Biorepository of H3Africa Uganda (IBRH3AU) Ouganda (pays nommé en fin d’affiliation)Institution
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College of Engineering pays non établi dans la noticeUniversité ou école supérieure
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MRC/UVRI and LSHTM Uganda Research Unit Entebbe Uganda, Ouganda (pays nommé en fin d’affiliation)Structure de recherche
Biophysics PhD program — University of California, Makerere University (Makerere University, Ouganda) et Berkeley College, avec 7 autres affiliations. Pays d’affiliation : Ouganda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.