57: Correlation of Anticoagulation Assays with Bleeding Complications During Extracorporeal Membrane Oxygenation: A 10-year Experience at a Tertiary Pediatric Hospital.
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Le résumé fourni par la source
Introduction: The use of Extracorporeal Membrane Oxygenation (ECMO) has shown improved survival amongst patients with potentially poor prognosis. No one anticoagulation assay has been superior to others in predicting hemorrhage. Our objective is to correlate the different anticoagulation assays with hemorrhage on ECMO at our center. Methods: We performed a retrospective chart review of patients admitted to the Pediatric ICU at the Children’s Hospital of San Antonio who required ECMO. Anticoagulation parameters were compared against clinical outcomes. Differences between groups were determined by the Wilcoxon rank sum test for the continuous variables and chi-square or Fisher’s exact tests for the categorical variables. Cumulative incidence of hemorrhage was depicted by the Kaplan-Meier (KM) curves. Logistic regression was used to determine coagulation factors associated with hemorrhage and mortality. Linear regression was used to determine the factors associated with the length of stay (LOS). Results: We included 76 patients between 2014 and 2023. Thirty-two (42.1%) patients experienced a hemorrhage. A larger proportion of survivors, (68.2%) was observed among those who did not experience hemorrhage. The incidence of hemorrhage at 10-, 20- and 30-days post-cannulation were 36.9% (26.2%-50.3%), 58.8% (41.9%-76.5%), and 72.5% (47.2%-92.7%), respectively. Those who had hemorrhage appeared to have significantly higher aPTT (p= 0.02). The odds of a hemorrhage increased with longer ECMO runs (OR=1.00 [1.001-1.01], p= 0.02; (OR=1.01 [1.002-1.01], p= 0.004). Conclusion: Our study demonstrated that a higher aPTT and longer duration of ECMO are independent factors associated with an increased risk of hemorrhage.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- 57: Correlation of Anticoagulation Assays with Bleeding Complications During Extracorporeal Membrane Oxygenation: A 10-year Experience at a Tertiary Pediatric Hospital.
- Date Crossref
- 01/09/2024
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Texas Southwestern Medical Center pays non établi dans la noticeÉtablissement de santé
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Baylor University pays non établi dans la noticeUniversité ou école supérieure
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Baylor College of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Christus Health pays non établi dans la noticeÉtablissement de santé
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Christus Santa Rosa Health System pays non établi dans la noticeÉtablissement de santé
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Le Bonheur Children's Hospital pays non établi dans la noticeÉtablissement de santé
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UTSW pays non établi dans la noticeInstitution
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Christus Children’s pays non établi dans la noticeInstitution
The University of Texas Southwestern Medical Center, Baylor University et Baylor College of Medicine, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.