The role of inflammation biomarkers in carotid artery stenosis procedures
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Le résumé fourni par la source
BACKGROUND: Carotid revascularization procedures, such as carotid endarterectomy (CEA) and carotid artery stenting (CAS), can lead to restenosis. Monitoring restenosis onset through biomarkers is crucial in clinical practice. This study aimed to evaluate inflammation biomarkers in CEA and CAS to determine their predictive value for restenosis risk postprocedure. METHODS: A retrospective analysis was conducted on the clinical records of patients with carotid stenosis who underwent CEA or CAS over 1 year at the vascular surgery departments of an interuniversity center. Eligible asymptomatic patients with carotid stenosis (70%-99%) underwent revascularization. Differences between preprocedural and early postprocedural inflammation indices were assessed, and restenosis risk was evaluated using receiver operating curve analysis and logistic regression. RESULTS: The cohort comprised 100 patients, 68 undergoing CEA and 32 undergoing CAS. Significant values were observed for inflammation ratios post-CEA: neutrophils to lymphocytes ratio (NLR) (P = 0.036), platelets to lymphocytes ratio (PLR) (P = 0.009), monocytes to lymphocytes ratio (MLR) (P < 0.001), systemic inflammation index (SII) (P = 0.024), systemic immune response index (SIRI) (P = 0.003), and aggregate inflammation response index (AISI) (P < 0.001). At 12-month follow-up, 12% of patients experienced restenosis; 50% were men and 50% women. Women showed a higher restenosis rate (26.1% vs 7.8%). Preintervention NLR (odds ratio {OR} [95% confidence interval {CI}] = 13.38 [1.88 to 95.44], P = 0.010) and SIRI (OR [95% CI] = 10.22 [2.65 to 39.43], P = 0.001) remained significantly associated with restenosis after adjusting for sex and smoking. CONCLUSIONS: The study provided a predictive model for restenosis, identifying preintervention NLR and SIRI as independent predictors of restenosis at 12-month follow-up.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The role of inflammation biomarkers in carotid artery stenosis procedures
- Date Crossref
- 01/01/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Magna Graecia University pays non établi dans la noticeUniversité ou école supérieure
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Iuliu Hațieganu University of Medicine and Pharmacy Department of Medical Informatics and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Sapienza University of Rome pays non établi dans la noticeUniversité ou école supérieure
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University of Naples Federico II pays non établi dans la noticeUniversité ou école supérieure
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University "Magna Graecia" of Catanzaro Department of Medical and Surgical Sciences pays non établi dans la noticeUniversité ou école supérieure
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"Sapienza" University of Rome Department of Public Health and Infectious Disease pays non établi dans la noticeUniversité ou école supérieure
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University of Naples "Federico II" Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
Magna Graecia University, Department of Medical Informatics and Biostatistics — Iuliu Hațieganu University of Medicine and Pharmacy et Sapienza University of Rome, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.