Genetic etiology of autism spectrum disorder in the African population: a scoping review
Rattachement africain : be, Rwanda, Ouganda. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by significant impairments in social, communicative, and behavioral abilities. However, only a limited number of studies address the genetic basis of ASD in the African population. This study aims to document the genes associated with ASD in Africa and the techniques used to identify them. Additionally, genes identified elsewhere but not yet in Africa are also noted. Methods Online databases such as Wiley Online Library, PubMed, and Africa Journal Online were used. The review was conducted using the keyword related to genetic and genomic ASD study in the African population. Result In this scoping review, 40 genetic studies on ASD in Africa were reviewed. The Egyptian and South African populations were the most studied, with 25 and 5 studies, respectively. Countries with fewer studies included Tunisia (4), East African countries (3), Libya (1), Nigeria (1), and Morocco (1). Some 61 genes responsible for ASD were identified in the African population: 26 were identified using a polymerase chain reaction (PCR)-based method, 22 were identified using sequencing technologies, and 12 genes and one de novo chromosomal aberration were identified through other techniques. No African study identified any ASD gene with genome-wide association studies (GWAS). Notably, at least 20 ASD risk genes reported in non-African countries were yet to be confirmed in Africa’s population. Conclusion There are insufficient genetic studies on ASD in the African population, with sample size being a major limitation in most genetic association studies, leading to inconclusive results. Thus, there is a need to conduct more studies with large sample sizes to identify other genes associated with ASD in Africa’s population using high-throughput sequencing technology.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Genetic etiology of autism spectrum disorder in the African population: a scoping review
- Date Crossref
- 26/09/2024
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Liège Centre Hospitalier Universitaire Sart-Tilman pays non établi dans la noticeUniversité ou école supérieure
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University of Rwanda Rwanda (code pays fourni par la source)Université ou école supérieure
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Centre Hospitalier Universitaire de Liège pays non établi dans la noticeÉtablissement de santé
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Centre Hospitalier Universitaire de Kigali Kigali, Rwanda (code pays fourni par la source)Établissement de santé
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Kampala International University Kampala International University, Ouganda (code pays fourni par la source)Université ou école supérieure
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University of Kigali University of Kigali, Rwanda (code pays fourni par la source)Université ou école supérieure
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Rwanda Biomedical Center Rwanda (code pays fourni par la source)Établissement de santé
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School of Medicine and Pharmacy Department of Biochemistry Kigali, Rwanda (pays nommé en fin d’affiliation)Université ou école supérieure
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University Teaching Hospital of Kigali (CHUK) Department of Pediatrics Kigali, Rwanda (pays nommé en fin d’affiliation)Université ou école supérieure
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College of Science and Technology Department of Biology Kigali, Rwanda (pays nommé en fin d’affiliation)Université ou école supérieure
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School of Pharmacy Department of Pharmacology and Toxicology Kampala International University, Ouganda (pays nommé en fin d’affiliation)Université ou école supérieure
Centre Hospitalier Universitaire Sart-Tilman — University of Liège, University of Rwanda (Rwanda) et Centre Hospitalier Universitaire de Liège, avec 8 autres affiliations. Pays d’affiliation : Rwanda, Ouganda.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.