Effects of online high‐definition transcranial direct current stimulation over left dorsolateral prefrontal cortex on predominant negative symptoms and EEG functional connectivity in patients with schizophrenia: a randomized, double‐blind, controlled trial
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Le résumé fourni par la source
AIMS: Schizophrenia, a debilitating mental disorder, is characterized by persistent negative symptoms such as avolition and anhedonia. Currently, there are no effective treatments available for these symptoms. Thus, our study aims to assess the efficacy of online high-definition transcranial direct current stimulation (online HD-tDCS) in addressing the negative symptoms of schizophrenia, utilizing a double-blind, randomized, sham-controlled trial design. METHODS: Fifty-nine patients with schizophrenia were randomized to receive either active HD-tDCS or sham stimulation, targeting the left dorsolateral prefrontal cortex. Outcomes were measured by changes in the Positive and Negative Syndrome Scale Factor Score for Negative Symptom (PANSS-FSNS). Exact low-resolution electromagnetic tomography was used to assess the functional connectivity. RESULTS: All 59 participants, including 50.84% females with an average age of 43.36 years, completed the trial. In the intention-to-treat analysis, patients receiving active HD-tDCS showed greater improvement in PANSS-FSNS scores compared to those receiving the sham procedure. The differences were 2.34 (95% confidence interval [CI], 1.28-3.40), 4.28 (95% CI, 2.93-5.62), and 4.91 (95% CI, 3.29-6.52) after the intervention, as well as at 1-week and 1-month follow-ups, respectively. A tingling sensation on the scalp was more common in the active group (63.3%) compared to the sham group (10.3%). Additionally, HD-tDCS was associated with a decrease in delta-band connectivity within the default mode network. CONCLUSIONS: High-definition transcranial direct current stimulation was effective and safe in ameliorating negative symptoms in patients with schizophrenia when combined with online functional targeting.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- <scp>Effects</scp> of online high‐definition transcranial direct current stimulation over left dorsolateral prefrontal cortex on predominant negative symptoms and <scp>EEG</scp> functional connectivity in patients with schizophrenia: a randomized, double‐blind, controlled trial
- Date Crossref
- 24/09/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Taipei University of Technology High‐Value Biomaterials Research and Commercialization Center pays non établi dans la noticeUniversité ou école supérieure
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Tri-Service General Hospital pays non établi dans la noticeÉtablissement de santé
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National Defense Medical Center pays non établi dans la noticeÉtablissement de santé
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National Central University pays non établi dans la noticeUniversité ou école supérieure
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Taoyuan Armed Forces General Hospital pays non établi dans la noticeÉtablissement de santé
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Tri-Service General Hospital Beitou Branch pays non établi dans la noticeÉtablissement de santé
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Catholic University of Korea pays non établi dans la noticeUniversité ou école supérieure
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National Health Research Institutes pays non établi dans la noticeOrganisation à but non lucratif
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Department of Psychiatry Tri‐Service General Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Emergency Medicine Tri‐Service General Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Nuclear Medicine College of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Institute of Biomedical Engineering and Nanomedicine pays non établi dans la noticeStructure de recherche
High‐Value Biomaterials Research and Commercialization Center — National Taipei University of Technology, Tri-Service General Hospital et National Defense Medical Center, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.