EEG measures of brain arousal in relation to symptom improvement in patients with major depressive disorder: Results from a randomized placebo-controlled clinical trial
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Le résumé fourni par la source
• EEG derived arousal stability is discussed as biomarker for response to antidepressants. • High arousal stability during a 2-min EEG at rest was associated with a better outcome in the sertraline arm, but worse outcome in the placebo arm. • Results indicate that arousal stability is likely to be a treatment-specific marker of antidepressant response. • Further out-of-sample validation is warranted. Hyperstable arousal regulation during a 15-min resting electroencephalogram (EEG) has been linked to a favorable response to antidepressants. The EMBARC study, a multicenter randomized placebo-controlled clinical trial, provides an opportunity to examine arousal stability as putative antidepressant response predictor in short EEG recordings. We tested the hypothesis that high arousal stability during a 2-min resting EEG at baseline is related to better outcome in the sertraline arm and explored the specificity of this effect. Outpatients with chronic/recurrent MDD were recruited from four university hospitals and randomized to treatment with sertraline ( n = 100) or placebo ( n = 104). The change in the Hamilton Rating Scale for Depression (HRSD-17) was the main outcome. Patients were stratified into high and low arousal stability groups. In mixed-model repeated measures (MMRM) analysis HRSD-17 change differed significantly between arousal groups, with high arousal stability being associated with a better outcome in the sertraline arm, and worse outcome in the placebo arm at week 4, with moderate effect sizes. When considering both treatment arms, a significant arousal group x time x treatment interaction emerged, highlighting specificity to the sertraline arm. Although findings indicate that arousal stability is likely to be a treatment-specific marker of response, further out-of-sample validation is warranted.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- EEG measures of brain arousal in relation to symptom improvement in patients with major depressive disorder: Results from a randomized placebo-controlled clinical trial
- Date Crossref
- 01/12/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Leipzig University pays non établi dans la noticeUniversité ou école supérieure
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Columbia University pays non établi dans la noticeUniversité ou école supérieure
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Universität der Bundeswehr München pays non établi dans la noticeUniversité ou école supérieure
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New York Psychoanalytic Society and Institute pays non établi dans la noticeInstitution
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New York State Psychiatric Institute pays non établi dans la noticeÉtablissement de santé
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Massachusetts General Hospital pays non établi dans la noticeÉtablissement de santé
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University of Michigan Departments of Psychology and Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Southwestern Medical Center Department of Psychiatry pays non établi dans la noticeÉtablissement de santé
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The University of Texas Southwestern Medical Center pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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McLean Hospital Department of Psychiatry pays non établi dans la noticeÉtablissement de santé
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Goethe University Frankfurt Research Center of the German Depression Foundation pays non établi dans la noticeUniversité ou école supérieure
Leipzig University, Columbia University et Universität der Bundeswehr München, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.