Clinical and pathological renal outcomes of COVID-19 patients: an Egyptian retrospective multi-center pooled analysis

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Abstract Background Kidneys have been one of the different organs affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since its discovery, Acute kidney injury was the most common presentation. A pooled data from different kidney centers or hospitals in Egypt who sent their renal biopsy specimens from patients with renal trouble, up to 4 months after catching SARS-CoV-2, to PATH LAB for diagnosis, were analyzed. Results Beside acute kidney injury, a variety of different presentations was found, such as accidentally discovered impaired kidney function, varying degrees of proteinuria, and nephrotic syndrome. Not only acute tubular injury, acute tubulointerstitial nephritis, or thrombotic microangiopathy, but the extent of observation for 4 months revealed, unexpected pathologies, such as podocytopathies, membranous glomerulonephritis, proliferative and necrotizing glomerulonephritis, and lupus nephritis. Conclusion This virus has been incriminated in a chain of different kidney disease presentations and pathologies, although, a causal relationship is difficult to prove.

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