Vitreoschisis‐induced vitreous cortex remnants in proliferative vitreoretinopathy: A comprehensive review from basic research to clinical practice
Rattachement africain : nl, be, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Proliferative vitreoretinopathy (PVR) significantly impacts the prognosis of rhegmatogenous retinal detachment (RRD), one of the most critical and increasing causes of vision loss in the Western world. Despite advancements in surgical instruments and techniques, the failure rate due to PVR remains substantial, necessitating additional surgeries and often leading to unsatisfactory visual outcomes. This comprehensive review explores the role of vitreoschisis-induced vitreous cortex remnants (VCR) as a critical, previously under-recognised factor contributing to PVR. Vitreoschisis, a phenomenon where the inner lamellae of the posterior vitreous cortex detach while the outermost layers remain attached to the retina, creates VCR that may contain hyalocytes and serve as scaffolds for fibrocellular proliferation. These remnants are difficult to visualise without triamcinolone acetonide (TA) staining, leading to their frequent lack of recognition in clinical practice. Moreover, removing VCR can be challenging and time-consuming, often requiring meticulous surgical techniques to avoid retinal damage and ensure complete elimination. This review consolidates insights from basic research and clinical practice, emphasising the importance of complete vitreous removal and effective VCR detection and removal to mitigate PVR risks. It highlights the histopathological and clinical evidence supporting the hypothesis that VCR, containing hyalocytes, play a pivotal role in preretinal membrane formation. The review also discusses epidemiological data, surgical management strategies and potential future directions, including improved visualisation techniques and the development of new surgical tools and methods. This review aims to improve surgical outcomes and reduce the frequency and burden of RRD-related complications by addressing VCR as a critical factor in PVR.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Vitreoschisis‐induced vitreous cortex remnants in proliferative vitreoretinopathy: A comprehensive review from basic research to clinical practice
- Date Crossref
- 11/09/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Erasmus MC pays non établi dans la noticeÉtablissement de santé
-
Combined Ophthalmic Research Rotterdam pays non établi dans la noticeOrganisation à but non lucratif
-
ZNA Middelheim Hospital pays non établi dans la noticeÉtablissement de santé
-
Doheny Eye Institute pays non établi dans la noticeStructure de recherche
-
Department of Ophthalmology Erasmus Medical Center Rotterdam The Netherlands pays non établi dans la noticeÉtablissement de santé
-
Rotterdam Ophthalmic Institute Rotterdam The Netherlands pays non établi dans la noticeStructure de recherche
-
Department of Vitreoretinal Surgery ZNA Middelheim Antwerp Belgium pays non établi dans la noticeInstitution
-
Retina Operation Center Utrecht The Netherlands pays non établi dans la noticeInstitution
-
VMR Institute for Vitreous Macula Retina Huntington Beach California USA pays non établi dans la noticeStructure de recherche
Erasmus MC, Combined Ophthalmic Research Rotterdam et ZNA Middelheim Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.