Daily Brain Metabolic Rhythms of Wild Nocturnal Bats

Le résumé fourni par la source

Circadian rhythms are found in a wide range of organisms and have garnered significant research interest in the field of chronobiology. Under normal circadian function, metabolic regulation is temporally coordinated across tissues and behaviors within a 24 h period. Metabolites, as the closest molecular regulation to physiological phenotype, have dynamic patterns and their relationship with circadian regulation remains to be fully elucidated. In this study, untargeted brain metabolomics was employed to investigate the daily rhythms of metabolites at four time points corresponding to four typical physiological states in Vespertilio sinensis. Key brain metabolites and associated physiological processes active at different time points were detected, with 154 metabolites identified as rhythmic. Analyses of both metabolomics and transcriptomics revealed that several important physiological processes, including the pentose phosphate pathway and oxidative phosphorylation, play key roles in regulating rhythmic physiology, particularly in hunting and flying behaviors. This study represents the first exploration of daily metabolic dynamics in the bat brain, providing insights into the complex regulatory network of circadian rhythms in mammals at a metabolic level. These findings serve as a valuable reference for future studies on circadian rhythms in nocturnal mammals.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.