Clinical Characteristics and Treatment Outcomes of Patients With Newly Diagnosed Takayasu Arteritis in Japan During the First 2 Years of Treatment ― A Nationwide Retrospective Cohort Study ―
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: This study aimed to clarify recent clinical features and treatment outcomes in Japanese patients with newly diagnosed Takayasu arteritis (TAK) during the first 2 years of treatment. METHODS AND RESULTS: A nationwide multicenter retrospective cohort study for TAK was implemented to collect data between 2007 and 2014. The primary outcome of the study was clinical remission at Week 24. Of the 184 participants registered, 129 patients with newly diagnosed TAK were analyzed: 84% were female and the mean age at onset was 35 years. Clinical symptoms at diagnosis were mostly associated with large-vessel lesions. Frequent sites of vascular involvement included the carotid artery, subclavian artery, aortic arch, and descending aorta. The mean initial dose of prednisolone administered was 0.68 mg/kg/day, and 59% and 17% of patients received immunosuppressive drugs and biologics, respectively, by Week 104. Clinical remission at Week 24 and sustained clinical remission with daily prednisolone at ≤10 mg at Week 52 were achieved in 107 (82.9%) and 51 (39.5%) patients, respectively. The presence of signs and symptoms linked to large-vessel lesions was associated with failure to achieve sustained clinical remission at Week 52. CONCLUSIONS: We elucidated the clinical characteristics, treatment outcomes, and factors associated with failure to achieve sustained clinical remission in patients with newly diagnosed TAK in Japan during the first 2 years of treatment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Characteristics and Treatment Outcomes of Patients With Newly Diagnosed Takayasu Arteritis in Japan During the First 2 Years of Treatment ― A Nationwide Retrospective Cohort Study ―
- Date Crossref
- 25/04/2025
- Éditeur
- Japanese Circulation Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Okayama University Department of Chronic Kidney Disease and Cardiovascular Disease pays non établi dans la noticeUniversité ou école supérieure
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National Cerebral and Cardiovascular Center Department of Vascular Physiology pays non établi dans la noticeÉtablissement de santé
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Tokyo Medical and Dental University Department of Cardiovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Toho University Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Kyoto University Department of Rheumatology pays non établi dans la noticeUniversité ou école supérieure
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Kawasaki Medical School pays non établi dans la noticeUniversité ou école supérieure
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St. Marianna University School of Medicine Department of Rheumatology and Allergology pays non établi dans la noticeUniversité ou école supérieure
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Shizuoka Medical Center pays non établi dans la noticeÉtablissement de santé
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National Hospital Organization pays non établi dans la noticeOrganisme public
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Kyorin University Department of Nephrology and Rheumatology pays non établi dans la noticeUniversité ou école supérieure
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University of Occupational and Environmental Health Japan The First Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Chronic Kidney Disease and Cardiovascular Disease — Okayama University, Department of Vascular Physiology — National Cerebral and Cardiovascular Center et The University of Osaka, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.