Formulation and Evaluation of Floating Microspheres of 1,1-Dimethylbiguanide

Résumé fourni par la source

1,1-Dimethylbiguanide is a hypoglycemic agent used in the treatment of non-insulin dependent Diabetes mellitus. It is a BCS Class –III drug having poor permeability. Plasma half life ranges from 1.5-3 hrs & oral bioavailability is 50-60%. Hence require frequent oral administration for adequate treatment of Diabetes in order to extend the gastric retention time oral sustained dosage form was developed in the form of microspheres using polymers (sodium CMC, HPMC K 100 M). The results presented that drug dissolution rate and drug entrapment increases while decreasing the polymer amount. All the formulations are evaluated for dissolution, entrapment efficiency, percentage buoyancy and 1,1-Dimethylbiguanide Microspheres of formulations, F-4 was found to be optimized formulation based on in-vitro release pattern and percentage buoyancy entrapment efficiency. Keywords: 1,1-Dimethylbiguanide, half-life formulations, efficiency.

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