Evaluation of local delivered platelet-rich fibrin versus Melatonin gel on the osseointegration of dental implant: a randomized controlled clinical trial

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Background and aim Dental implant is a dental treatment that allow oral rehabilitation for partial and fully edentulous patients. Osseointegration is the factor that control success or failure of dental implant that can be improved by addition of different adjunctive biological materials. Platelet-rich fibrin (PRF) membrane plays a significant role in tissue regeneration and wound healing. Melatonin (MNL) is biological hormone that secreted from pineal gland and played an important role in human growth. Patients and methods The present controlled clinical trial was carried out to evaluate one-stage dental implant with local application of MNL gel versus PRF membrane as a biomimetic material clinically and radiographically. 30 female patients with missing mandibular premolars- molar were randomized to receive 30 dental implants. Group A (10 patient) control group with dental implant only, group B (10 patient) test group with application of PRF membrane and group C (10 patient) test group with application of MNL gel. Patients were followed up at baseline (before implant placement to record both gingival thickness and bone density and immediately after implant placement to record marginal bone loss), 2 weeks, and 6 months. Results At 6 months follow up, there were significant improvement in gingival thickness and bone density in PRF membrane and MNL gel groups, while the preservation of marginal bone level loss was significant in MNL gel group than other two groups. Conclusions The current results shown that PRF membrane and MNL gel can be used to improve both hard and soft tissue around implant with increased efficiency of MNL regarding marginal bone loss.

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