Prenatal exposure to PM2.5 and its composition on child growth trajectories in the first two years: A prospective birth cohort study

Le résumé fourni par la source

The findings on the relationship between prenatal exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM 2.5 ) and its constituent and children's growth trajectories are inconsistent. This association's sensitive exposure time window and possible gender differences remain unclear. Our aim was to determine the association between prenatal exposure to PM 2.5 and its component and children's growth trajectories by the age of two. From 2015 to 2021, 6407 mother-infant pairs were enrolled in the study. The PM 2.5 include sulfate (SO 4 2− ), nitrate (NO 3 − ), ammonium (NH 4 + ), organic matter (OM), and black carbon (BC), from the ChinaHighAirPollutants (CHAP) datasets. Children were followed at birth, 1, 3, 6, 9, 12, 18, and 24 months. Population-based and individual-based methods were used to simulate child growth trajectories: slow growth, normal growth, and rapid growth. The distributed lags modeling was used to identify sensitive time windows for the effects of prenatal exposure to PM 2.5 and its components on child growth. Sex-stratified analyses estimated sex differences. Median concentrations [interquartile ranges (IQRs)] were 57.46(17.3), 10.59(3.8), 14.26(4.4), 8.69(2.8), 13.05(3.4), and 2.53(0.7) μg/m 3 for PM 2.5 , SO 4 2− , NO 3 − , NH 4 + , OM, and BC, respectively. Compared with the normal growth trajectory group, exposure to PM 2.5 was significantly associated with a higher risk of rapid growth trajectory in boys ( OR s with 95% CI for the entire, first trimester, and second trimester of pregnancy, respectively: 1.016[1.006,1.025], 1.007[1.002,1.011], 1.007[1.002,1.011]). Exposure to PM 2.5 was significantly associated with a higher risk of slow growth trajectory in girls ( OR s with 95% CI for the entire, second trimester, and third trimester of pregnancy, respectively: 1.010 [1.001,1.018], 1.006 [1.001,1.011], 1.007 [1.002,1.012]). Prenatal PM 2.5 and its composition exposure was positively associated with BMI peak in boys ( β s with 95% CI for PM 2.5 , SO 4 2− , NO 3 − , NH 4 + , OM, BC: 0.004[0.000,0.007], 0.025[0.006,0.044], 0.012[0.002,0.023], 0.022[0.004,0.039], 0.016[0.001,0.031], 0.082[0.005,0.159]), and not statistically significant in girls. We observed a more pronounced BC effect in our cohort. Prenatal exposure to PM 2.5 and its component, especially at 10–22 weeks of gestation, is associated with a higher risk of rapid growth in boys and a risk of slow growth in girls. • Prenatal exposure to PM 2.5 its component is likely a higher risk of rapid growth in boys. • Prenatal exposure to PM 2.5 its component is likely a higher risk of slow growth in girls. • We objectively identify sensitive windows of prenatal PM 2.5 its component. • Body mass index (BMI) peak was modeled using an individual-based BMI growth curve accounts. • We observed a more pronounced black carbon (BC) effect in our cohort.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.