Early Biological Response to Poly(ε-Caprolactone)/Alumina-Toughened Zirconia Composites Obtained by 3D Printing for Peri-Implant Application
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Le résumé fourni par la source
The improvement of the mucosal sealing around the implant represents a challenge, one that prompted research into novel materials. To this purpose, a printable poly(ε-caprolactone) (PCL)-based composite loaded with alumina-toughened zirconia (ATZ) at increasing rates of 10, 20, and 40 wt.% was prepared, using a solvent casting method with chloroform. Disks were produced by 3D printing; surface roughness, free energy and optical contact angle were measured. Oral fibroblasts (PF) and epithelial cell (SG) tests were utilized to determine the biocompatibility of the materials through cell viability assay and adhesion and spreading evaluations. The highest level of ATZ resulted in an increase in the average roughness (Sa), while the maximum height (Sz) was higher for all composites than that of the unmixed PCL, regardless of their ATZ content. Surface free energy was significantly lower on PCL/ATZ 80/20 and PCL/ATZ 60/40, compared to PCL and PCL/ATZ 90/10. The contact angle was inversely related to the quantity of ATZ in the material. PF grew without variations among the different specimens at 1 and 3 days. After 7 days, PF grew significantly less on PCL/ATZ 60/40 and PCL/ATZ 80/20 compared to unmixed PCL and PCL 90/10. Conversely, ATZ affected and improved the growth of SG. By increasing the filler amount, PF cell adhesion and spreading augmented, while PCL/ATZ 80/20 was the best for SG adhesion. Overall, PCL/ATZ 80/20 emerged as the best composite for both cell types; hence, it is a promising candidate for the manufacture of custom made transmucosal dental implant components.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Early Biological Response to Poly(ε-Caprolactone)/Alumina-Toughened Zirconia Composites Obtained by 3D Printing for Peri-Implant Application
- Date Crossref
- 05/09/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Politecnico di Torino pays non établi dans la noticeUniversité ou école supérieure
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University of Turin Bone and Dental Bioengineering Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Accademia Albertina delle Belle Arti pays non établi dans la noticeUniversité ou école supérieure
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Istituto Nazionale di Ricerca Metrologica pays non établi dans la noticeStructure de recherche
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Department of Mechanical and Aerospace Engineering pays non établi dans la noticeInstitution
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Institute of Sciences and Technologies for Sustainable Energy and Mobility pays non établi dans la noticeStructure de recherche
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Applied Metrology and Engineering Division pays non établi dans la noticeInstitution
Politecnico di Torino, Bone and Dental Bioengineering Laboratory — University of Turin et Accademia Albertina delle Belle Arti, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.