Enhanced exploration of the mode of action of a five-layer foam dressing: critical properties to support wound healing
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Le résumé fourni par la source
Objective: The aim of this in vitro experimental series was to explore the mode of action of a hydrocellular polyurethane foam dressing (HPFD) and how its advanced features support beneficial interactions with the wound bed to address common barriers to wound healing, thus supporting improved clinical outcomes. Method: Multiple in vitro microbiological tests were performed, assessing prevention of bacterial ingress, surface removal of bacteria, bacterial sequestration and retention into the dressing in a clinically relevant environment. Odour molecule concentrations were measured using gas chromatography and further assays explored matrix metalloproteinase (MMP)-9 retention in the dressing using enzyme linked immunosorbent assay. Results: The HPFD demonstrated marked reductions in bioburden levels across multiple tests. These included prevention of bacterial ingress for seven days, removal of surface bacteria and absorption into the dressing. Further tests identified that most bacteria were sequestered into the hyperabsorbent layer (90.5% for Pseudomonas aeruginosa and 89.6% for meticillin-resistant Staphylococcus aureus). Moreover, the majority of bacteria (99.99% for both test organisms) were retained within the dressing, even upon compression. Additional tests demonstrated a marked reduction of odour molecules following incubation with HPFD and total retention of protease MMP-9 within the dressing. Conclusions: Proactive management of the wound environment with an appropriate advanced wound dressing, such as the HPFD examined in these in vitro investigations, can not only help to minimise the barriers to healing, as observed across this test series by direct interaction with the wound bed, but may, as a result, provide an ideal environment for wound progression with minimal disturbance.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Enhanced exploration of the mode of action of a five-layer foam dressing: critical properties to support wound healing
- Date Crossref
- 02/09/2024
- Éditeur
- Mark Allen Group
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Huddersfield Institute of Skin Integrity and Infection Prevention pays non établi dans la noticeUniversité ou école supérieure
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Royal College of Surgeons in Ireland Visiting Professor pays non établi dans la noticeUniversité ou école supérieure
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Queensland University of Technology pays non établi dans la noticeUniversité ou école supérieure
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Smith & Nephew (United Kingdom) pays non établi dans la noticeEntreprise
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School of Nursing Adjunct Professor pays non établi dans la noticeUniversité ou école supérieure
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Clinical and Scientific Consultant pays non établi dans la noticeÉtablissement de santé
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Research and Development pays non établi dans la noticeInstitution
Institute of Skin Integrity and Infection Prevention — University of Huddersfield, Visiting Professor — Royal College of Surgeons in Ireland et Queensland University of Technology, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.