Accès ouvert déclaré 2024 preprint

Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement

Emma Short, Ian M. Adcock, Bilal Al-Sarireh, Ann Ager, Ramzi Ajjan, Naveed Akbar, Michael A. Akeroyd, Ghada Alsaleh, Ghada Al-Sharbatee, Kambiz N. Alavian, Winfried M. K. Amoaku, Julie K. Andersen, Chrystalina A. Antoniades, Mark J. Arends, Sue Astley, Denize Atan, Richard Attanoos, Johannes Attems, Stephen C. Bain, Konstantinos Balaskas, Gabriel Balmus, Manohar Bance, Thomas Barber, Ajoy Bardhan, Karen Barker, Peter J. Barnes, Gemma Basatemur, Adrian C Bateman, Moisés Evandro Bauer, Christopher Bellamy, Edwin J.R. van Beek, Ilaria Bellantuono, E W Benbow, Sunil Bhandari, Rahul Bhatnagar, Philip Bloom, Dawn M. E. Bowdish, Mélissa Bowerman, Melanie Rose Burke, Roxana O. Carare, Emma V. Carrington, Jorge Iván Castillo-Quan, Peter Clegg, James H. Cole, Carlo Cota, Paul L. Chazot, Christopher Chen, Ying Cheong, Gary Christopher, David J. Clancy, Paul Cool, Francesco Del Galdo, Mayank Dalakoti, Soumit Dasgupta, Colleen S. Deane, Devesh Dhasmana, Stefan Dojcinov, Monia Di Prete, Huaidong Du, Niharika A. Duggal, Toby J. Ellmers, Costanza Emanueli, Mark Emberton, Jorge D. Erusalimsky, Laurence Feldmeyer, G. Alexander Fleming, Karen Forbes, Thomas C. Foster, Daniela Frasca, Ian M. Frayling, Daniel Freedman, Tamàs Fülöp, Georgina M. Ellison, Gus Gazzard, Christopher H. George, Jesús Gil, Richard J. Glassock, Robert Goldin, John R. Green, Robyn H. Guymer, Hasan Haboubi, Lorna Harries, Simon P. Hart, Douglas E. H. Hartley, Sebri Hasaballa, Christin Henein, Maggie Helliwell, Emily J. Henderson, Rakesh Heer, Iskander Idris, David Isenberg, Juulia Jylhävä, Ahmed Iqbal, Simon W. Jones, Raj N. Kalaria, Venkateswarlu Kanamarlapudi, Werner Kempf, Alexandra Kermack, Jemma G. Kerns, Albert Koulman, Adnan Khan, James Kinross, Katarina Klaucane, Yamini Krishna, H.S. Gill, Edward G. Lakatta, Ezio Laconi, Alpár S. Lázár, Christiaan Leeuwenburgh, Samantha Leung, Xuan Li, Ian van der Linde, Luı́sa V. Lopes, Antonello Lorenzini, Andrew Lotery, Pedro Machado, Sarah Mackie, Paolo Madeddu, Andrea B. Maier, Krishna Mukkanna, Pinelopi Manousou, Oonagh Markey, Claudio Mauro, Barry J. McDonnell, Reinhold J. Medina, Soma Meran, Claudia Metzler‐Baddeley, Ignor Meglinksi, Neta Milman, Ruth R. Montgomery, Andrew Conway Morris, Beda Mühleisen, Abhik Mukherkee, Andrew J. Murray, Scott M. Nelson, Anna Nicolaou, Alexander Nirenberg, Simon Noble, Lisa S. Nolan, Meritxell Nus, Canh Van On, Victor Osei-Lah, Mandy J. Peffers, Antony Palmer, Donald Palmer, William Parry‐Smith, Graham Pawelec, Shahaf Peleg, Rasika Perera, Andrew A. Pitsillides, Christopher J. Plack, Franze Progatzsky, Sonja J. Pyott, Kaukab Rajput, Sameera Rashid, J. Arjuna Ratnayaka, Sudhira Ratnayake, Manuel Rodriguez‐Justo, Arianna Carolina Rosa, Andrew D. Rule, Gareth J. Sanger, Ian Sayers, Andrew J. Saykin, Dinesh Selvarajah, Jaswinder K. Sethi, Shai S. Shen-Orr, Carl Sheridan, Paul G. Shiels, Kastytis Šidlauskas, Sobha Sivaprasad, Judith C. Sluimer, Gary W. Small, Peter J. Smith, Rebecca Smith, Sarah Snelling, Ioakim Spyridopoulos, Rohini Raghavan, David Steel, Karen P. Steel, Claire E. Stewart, Keeron Stone, Selvarani Subbarayan, Mark A. Sussman, Jonas E. Svensson, Vyshnavi Tadanki, Ai Lyn Tan, Rudolph E. Tanzi, Amanda L. Tatler, Adriana Tavares, Tengku Amatullah Madeehah Tengku Mohd, Ana Tiganescu, James A. Timmons, Jeremy J. Tree, Drupad K. Trivedi, Emmanuel Tsochatzis, Dialechti Tsimpida, Elisabeth J. Vinke, Neeru A. Vallabh, Kristin Veighey, Zoe C Venables, Venkat Reddy, Meike W. Vernooij, Chris P. Verschoor, Manlio Vinciguerra, Vesna Vukanovic, Vladyslav V. Vyazovskiy, James J. Walker, Richard J. Wakefield, Adam J. Watkins, A Webster, Caroline M. Weight, Birgit Weinberger, Susan L. Whitney, R. F. Willis, Jacek M. Witkowski, Leonard L.L. Yeo, T. Chung, Emma Yu, Michael B. Zemel, Stuart Calimport, Barry L. Bentley

2Citations signalées, ce qui n’est pas une note de qualité

117Institutions déclarées

19Pays d’affiliation déclarés

Rattachement africain : gb, us, br, dk, ca, it, sg, ch, au, fi, se, pt, nl, il, de, my, bg, at, pl. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Background: Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased healthspan. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity, and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand, and meet the healthcare, workforce, wellbeing, and socioeconomic needs of ageing populations, while supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. Methods: , 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of ≥70% for approval. Results: The accepted criteria for an ageing-related pathology, disease or syndrome were: Develops and/or progresses with increasing chronological age.Should be associated with, or contribute to, functional decline, or an increased susceptibility to functional decline.Evidenced by studies in humans. Conclusions: Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement
Date Crossref: 03/09/2024
Éditeur: openRxiv
Type: posted-content

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

Swansea Bay University Health Board Cardiff Metropolitan University Imperial College London Cardiff University University of Leeds University of Oxford University of Nottingham West Midlands Deanery Buck Institute for Research on Aging University of Edinburgh University of Manchester University of Bristol Cardiff and Vale University Health Board Newcastle University Swansea University Moorfields Eye Hospital University College London University of Cambridge University Hospitals Coventry and Warwickshire NHS Trust University of Warwick University of Birmingham University of Southampton Pontifícia Universidade Católica do Rio Grande do Sul University of Sheffield Hull York Medical School North Bristol NHS Trust University of Southern Denmark McMaster University Robert Jones and Agnes Hunt Orthopaedic Hospital Keele University Harvard University University of Liverpool San Gallicano Hospital Durham University National University of Singapore Lancaster University National University Heart Centre Singapore Alder Hey Children's Hospital University of St Andrews St Andrew's Healthcare University Hospital of Bern Infineum (United States)University of Florida University of Miami Surrey and Sussex Healthcare NHS Trust Université de Sherbrooke King's College London MRC London Institute of Medical Sciences The University of Melbourne Centre for Eye Research Australia University of Exeter National Institute for Health and Care Research University of Ulster Royal Victoria Hospital Tampere University Karolinska Institutet Tampere University University Hospital Zurich University of Surrey University of Iowa St Thomas' Hospital Aintree University Hospitals NHS Foundation Trust University of Bath National Institute on Aging University of Cagliari University of East Anglia Lagan Valley Hospital Anglia Ruskin University University of Lisbon Lusíada University of Lisbon University of Bologna Leeds Teaching Hospitals NHS Trust University of Amsterdam Imperial College Healthcare NHS Trust Loughborough University Aston University Technion – Israel Institute of Technology Yale University University of Basel University of Glasgow Australasian College for Emergency Medicine Portsmouth Hospitals NHS Trust Royal Veterinary College Health Sciences North University of Tübingen Research Institute for Farm Animal Biology (FBN)Guy's and St Thomas' NHS Foundation Trust Great Ormond Street Hospital The Christie NHS Foundation Trust University of Turin WinnMed Mayo Clinic in Florida Queen Mary University of London University School Indiana University School of Medicine Indiana University Maastricht University RWTH Aachen University Hackensack Meridian Health Royal Surrey NHS Foundation Trust Sunderland Eye Infirmary Liverpool John Moores University NIHR Research Delivery Network University of Aberdeen San Diego State University Massachusetts General Hospital Universiti Sains Islam Malaysia Erasmus MC Erasmus University Rotterdam University of Stirling Norfolk and Norwich University Hospital Medical University of Varna Universität Innsbruck University of Pittsburgh Gdańsk Medical University University of Tennessee at Knoxville Shriners Hospitals for Children - Boston

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Frailty in Older AdultsChronic Disease Management StrategiesNutrition and Health in Aging

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