31 Operational Recommendations for Streamlining Emergency Research Responses to Pandemics

Résumé fourni par la source

Abstract This chapter describes clinical research operations and some of the obstacles to accelerated research response during Ebola outbreaks since 2014 and the coronavirus disease 2019 (COVID-19) pandemic. It makes recommendations for streamlining operational requirements in order to accelerate research response without comprising ethical and scientific rigor. The Ebola outbreaks provided invaluable experience in emergency research operations in resource-poor settings for hundreds of research staff and served as a proving ground for rapid implementation of clinical research. They helped broaden acceptance of expedited clinical research as an integral part of emergency response to an infectious disease outbreak with pandemic potential. The COVID-19 outbreak offered further lessons for assessment of future vaccines, therapeutics, and diagnostics (VTDs) in time to mitigate morbidity and mortality during the course of the pandemic. Illustrative research programs include the Randomised Evaluation of COVID-19 Therapy (RECOVERY) study in the UK and the US-based Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) studies. Learning from these and other response research programs can guide swift, coherent, and flexible research response to new public health emergencies if sufficient funding is available for preparedness and response.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.