Efficacy of a Diabetes Specific Nutrition Supplement on Glycemic, Anthropometric, Dietary and Gut Health Markers in Adults with Type 2 Diabetes: An RCT

Le résumé fourni par la source

With increasing incidence of diabetes, use of diabetes specific nutrition supplements (DSNS) is common for better management of the disease. To study effect of 12-week DSNS supplementation on glycemic markers, anthropometry, lipid profile, SCFAs, and gut microbiome in individuals with diabetes. Markers studied were glycemic [Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excursions (MAGE), Time in/above Range (TIR/TAR)], anthropometry [weight, Body Mass Index (BMI), waist circumference (WC)], lipid profile, diet and gut health [plasma short chain fatty acids (SCFAs)]. N = 210 adults were randomized to receive either DSNS with standard care (DSNS + SC; n = 105) or standard care alone (SC alone; n = 105). After 12 weeks, significant differences between DSNS + SC versus SC alone was observed in FBG [−3 ± 6 vs 14 ± 6 mg/dl; p = 0.03], PPG [−35 ± 9 vs −3 ± 9 mg/dl; p = 0.01], weight [−0.6 ± 0.1 vs 0.2 ± 0.1 kg; p = 0.0001], BMI [−0.3 ± 0.1 vs 0.1 ± 0.1 kg/m2; p = 0.0001] and WC [−0.3 ± 0.2 vs 0.2 ± 0.2 cm; p = 0.01]. HbA1C and low-density lipoprotein (LDL) were significantly reduced in DSNS + SC [−0.2 ± 0.9; p = 0.04 and −5 mg/dl; p = 0.03] respectively with no change in control. Continuous Glucose Monitoring (CGM) reported significant differences between DSNS + SC versus SC alone for mean glucose [−12 ± 65 vs 28 ± 93 mg/dl; p < 0.01], TAR 180 [−9 ± 42 vs 7 ± 45 mg/dl; p = 0.04], TAR 250 [−3 ± 27 vs 9 ± 38 mg/dl; p = 0.05], iAUC [−192 (1.1) vs −48 (1.1) mg/dl; p = 0.03]. MAGE was significantly reduced for both DSNS + SC (−19 ± 67; p < 0.001) and SC alone (−8 ± 70; p = 0.04), with reduction being more pronounced for DSNS + SC. DSNS + SC reported a decrease in carbohydrate energy % [−9.4 (−11.3, −7.6) %; p < 0.0001] and amount [−47.4 (−67.1, −27.7) g; p < 0.0001], increased dietary fiber [9.5 (7.2, 11.8) g; p < 0.0001] and protein energy % [0.9 (0.5, 1.3) %; p < 0.0001] versus SC alone. DSNS + SC reported significant increases versus SC alone in total (0.3 ng/ml; p = 0.03) and individual plasma SCFAs. The consumption of DSNS significantly improves the glycemic, anthropometric, dietary, and gut health markers in diabetes.

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