The Effect of THz Electromagnetic Field on the Conductance of Potassium and Sodium Channels

Le résumé fourni par la source

Abstract Ion channels are essential to various physiological processes and their defects are associated with many diseases. Previous research has revealed that Terahertz electromagnetic field can alter the channel conductance by affecting the motion of chemical groups of ion channels, and hence regulate the electric signals of neurons. In this study, we conducted molecular dynamics simulations to systematically investigate the effects of terahertz electromagnetic fields on the conductance of voltage-gated potassium and sodium channels, particularly focusing on the bound ions in the selectivity filters that have not been studied previously. Our results identified multiple new characteristic frequencies and showed that 1.4, 2.2, or 2.9 THz field increases the conductance of K v 1.2, and 2.5 or 48.6 THz field increases the conductance of Na v 1.5. The conductance-enhancing effects are specific to the frequencies and directions of the electric field, which are determined by the intrinsic oscillation motions of the permeating ions in the selectivity filter or certain chemical groups of the ion channels. The amplitude of the THz field positively correlates with the change in ion conductance. Therefore, this study demonstrates that THz fields can specifically regulate ion channel conductances, which may carry great potential in biomedical applications.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.