Helicobacter pylori might be a contributing factor in gallbladder polyps or gallstones: A single center case-control matching study of Turkish individuals

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Background/Purpose: In recent studies, Helicobacter pylori (Hp) infection; It was stated that it may be associated with diseases such as obesity, diabetes, chronic obstructive pulmonary disease and kidney failure. In our study, we aimed to examine the relationship between Hp infection and gallstones and gallbladder polyps. Methods: Patients who underwent elective cholecystectomy between January 2017 and December 2021 were retrospectively examined. Patients were divided into those with only polyps in the gallbladder (Group P), those with polyps and stones together (Group SP), and those with only stones (Group S). The control group consisted of patients who underwent gastroscopy due to dyspeptic complaints (Group No). The groups were screened for the presence of Helicobacter pylori. Demographic data, comorbidities, presence of hepatosteatosis and laboratory values were recorded and compared. Results: 244 patients were included in the study. HP was positive in 141 (57.8%) of the patients and negative in 103 (42.2%). There were 58 (23.8%) patients in Group P, 22 (9%) in Group SP, 90 (36.9%) in Group S, and 74 (30.3%) in Group No. There was a significant difference in age between Group P and Group No (P = 0.012). Female gender was significantly higher in Group S (P=0.009). Helicobacter pylori positivity rate was significantly higher in Group P and Group SP (P = 0.012). Conclusion: HP infection may be associated with gallbladder polyps. We recommend that prospective randomized controlled studies be supported by large sample data.

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