Genome Tunisia Project: paving the way for precision medicine in North Africa
Rattachement africain : Tunisie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Key discoveries and innovations in the field of human genetics have led to the foundation of molecular and personalized medicine. Here, we present the Genome Tunisia Project, a two-phased initiative (2022-2035) which aims to deliver the reference sequence of the Tunisian Genome and to support the implementation of personalized medicine in Tunisia, a North African country that represents a central hub of population admixture and human migration between African, European, and Asian populations. The main goal of this initiative is to develop a healthcare system capable of incorporating omics data for use in routine medical practice, enabling medical doctors to better prevent, diagnose, and treat patients. METHODS: A multidisciplinary partnership involving Tunisian experts from different institutions has come to discern all requirements that would be of high priority to fulfill the project's goals. One of the most urgent priorities is to determine the reference sequence of the Tunisian Genome. In addition, extensive situation analysis and revision of the education programs, community awareness, appropriate infrastructure including sequencing platforms and biobanking, as well as ethical and regulatory frameworks, have been undertaken towards building sufficient capacity to integrate personalized medicine into the Tunisian healthcare system. RESULTS: In the framework of this project, an ecosystem with all engaged stakeholders has been implemented including healthcare providers, clinicians, researchers, pharmacists, bioinformaticians, industry, policymakers, and advocacy groups. This initiative will also help to reinforce research and innovation capacities in the field of genomics and to strengthen discoverability in the health sector. CONCLUSIONS: Genome Tunisia is the first initiative in North Africa that seeks to demonstrate the major impact that can be achieved by Human Genome Projects in low- and middle-income countries to strengthen research and to improve disease management and treatment outcomes, thereby reducing the social and economic burden on healthcare systems. Sharing this experience within the African scientific community is a chance to turn a major challenge into an opportunity for dissemination and outreach. Additional efforts are now being made to advance personalized medicine in patient care by educating consumers and providers, accelerating research and innovation, and supporting necessary changes in policy and regulation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Genome Tunisia Project: paving the way for precision medicine in North Africa
- Date Crossref
- 27/08/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tunis University Tunis University, Tunisie (code pays fourni par la source)Université ou école supérieure
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Institut Pasteur de Tunis Science and Society Support Unit (UniSS) Institut Pasteur de Tunis, Tunisie (code pays fourni par la source)Structure de recherche
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Tunis El Manar University Tunis El Manar University, Tunisie (code pays fourni par la source)Université ou école supérieure
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Faculté de médecine de Tunis Faculté de médecine de Tunis, Tunisie (ville ou établissement reconnu, pays non nommé)Université ou école supérieure
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University of Sfax Laboratory of Molecular and Cellular Screening Processes University of Sfax, Tunisie (code pays fourni par la source)Université ou école supérieure
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Hopital Universitaire Hedi Chaker Tunisie (code pays fourni par la source)Établissement de santé
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Centre of Biotechnology of Sfax Centre of Biotechnology of Sfax, Tunisie (code pays fourni par la source)Structure de recherche
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Hôpital Mongi Slim Tunisie (code pays fourni par la source)Établissement de santé
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Hôpital Farhat Hached Tunisie (code pays fourni par la source)Établissement de santé
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University of Sousse University of Sousse, Tunisie (code pays fourni par la source)Université ou école supérieure
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University of Monastir University of Monastir, Tunisie (code pays fourni par la source)Université ou école supérieure
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Faculty of Medicine of Sfax Laboratory of Human Molecular Genetics Faculty of Medicine of Sfax, Tunisie (pays nommé en fin d’affiliation)Université ou école supérieure
Tunis University (Tunis University, Tunisie), Science and Society Support Unit (UniSS) — Institut Pasteur de Tunis (Institut Pasteur de Tunis, Tunisie) et Tunis El Manar University (Tunis El Manar University, Tunisie), avec 9 autres affiliations. Pays d’affiliation : Tunisie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.