Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort
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Le résumé fourni par la source
Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990–1991 Gulf War. Fatigue, GI complaints, and other chronic symptoms continue to persist more than 30 years post-deployment. Several potential mechanisms for the persistent illness have been identified and our prior pilot study linked an altered gut microbiome with the disorder. This study further validates and builds on our prior preliminary findings of host gut microbiome dysbiosis in veterans with GWI. Using stool samples and Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases and 26 controls) from the Boston biorepository, recruitment, and integrative network (BBRAIN) for Gulf War Illness, we found that the host gut bacterial signature of veterans with GWI showed significantly different Bray–Curtis beta diversity than control veterans. Specifically, a higher Firmicutes to Bacteroidetes ratio, decrease in Akkermansia sp., Bacteroides thetaiotamicron, Bacteroides fragilis, and Lachnospiraceae genera and increase in Blautia, Streptococcus, Klebsiella, and Clostridium genera, that are associated with gut, immune, and brain health, were shown. Further, using MaAsLin and Boruta algorithms, Coprococcus and Eisenbergiella were identified as important predictors of GWI with an area under the curve ROC predictive value of 74.8%. Higher self-reported MFI scores in veterans with GWI were also significantly associated with an altered gut bacterial diversity and species abundance of Lachnospiraceae and Blautia. These results suggest potential therapeutic targets for veterans with GWI that target the gut microbiome and specific symptoms of the illness.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort
- Date Crossref
- 21/08/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of California Department of Psychiatry and Behavioral Sciences pays non établi dans la noticeUniversité ou école supérieure
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Cosmos Corporation (United States) pays non établi dans la noticeEntreprise
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Nova Southeastern University Institute for Neuro-Immune Medicine pays non établi dans la noticeUniversité ou école supérieure
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Miami VA Healthcare System pays non établi dans la noticeÉtablissement de santé
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San Francisco VA Health Care System pays non établi dans la noticeÉtablissement de santé
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James J. Peters VA Medical Center pays non établi dans la noticeÉtablissement de santé
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Icahn School of Medicine at Mount Sinai Psychiatry Department pays non établi dans la noticeUniversité ou école supérieure
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Boston University Department of Environmental Health pays non établi dans la noticeUniversité ou école supérieure
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University of Utah pays non établi dans la noticeUniversité ou école supérieure
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Susan and Henry Samueli College of Health Sciences Environmental Health and Disease Laboratory pays non établi dans la noticeUniversité ou école supérieure
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CosmosID pays non établi dans la noticeInstitution
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VA Long Beach Health Care VA Research and Development pays non établi dans la noticeOrganisation à but non lucratif
Department of Psychiatry and Behavioral Sciences — University of California, Cosmos Corporation (United States) et Institute for Neuro-Immune Medicine — Nova Southeastern University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.