Metabolomic Profiling of Guadua Species and Its Correlation with Antioxidant and Cytotoxic Activities
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Le résumé fourni par la source
High Resolution Image Download MS PowerPoint Slide Bamboo plants are widely used in Asian traditional medicine for various health issues and exhibit therapeutic potential. Guadua species are renowned bamboos for their high phenolic compound content, including flavonoids and hydroxycinnamic acid derivatives, and possess noteworthy biological properties. Despite this, there is a notable scarcity of research on the chemical and biological aspects of Latin American bamboo leaf extracts (BLEs), especially concerning the Guadua genus. This study aimed to employ a metabolomics approach to integrate the phytochemical and activity profiles of BLEs to identify potential bioactive markers. We determined the metabolic fingerprints of 30 BLEs through HPTLC, HPLC-DAD, UHPLC-QTOF-MS, and 1 H-NMR analyses and screened for antioxidant and cytotoxic activities using ABTS, DPPH, and MTT methods. Ultimately, correlation analyses were performed by using chemometric methods and molecular networking. Our findings present a comprehensive chemical characterization, encompassing 40 flavonoids and 9 cinnamic acid derivatives. Notably, most of these compounds have been reported for the first time within the genus, signifying novel discoveries. Additionally, certain compounds identified in other species of the subfamily Bambusoideae provide valuable comparative insights. These compounds demonstrated a significant correlation with antioxidant potential, with values exceeding 100 and 30 μmol of TE/g of extract for ABTS and DPPH, respectively, in the samples. Extracts from G. incana and G. angustifolia exhibited potent cytotoxic effects with IC 50 values of 1.23 and 4.73 μg/mL against HCT-116 colon cancer cells, respectively. Notably, glycosylated flavones showed a strong correlation with cytotoxicity. These new findings significantly contribute to our understanding of the chemical composition and biological properties of these often overlooked bamboo species, providing them with important added value and alternative use.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Metabolomic Profiling of <i>Guadua</i> Species and Its Correlation with Antioxidant and Cytotoxic Activities
- Date Crossref
- 21/08/2024
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Pontificia Universidad Javeriana pays non établi dans la noticeUniversité ou école supérieure
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Natura (Brazil) pays non établi dans la noticeEntreprise
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Universidade Estadual Paulista (Unesp) pays non établi dans la noticeUniversité ou école supérieure
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Universidade de São Paulo pays non établi dans la noticeUniversité ou école supérieure
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Universidad Nacional de Colombia pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Sciences Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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São Paulo State University (UNESP) Institute of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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University of São Paulo Institute of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Agricultural Sciences pays non établi dans la noticeUniversité ou école supérieure
Pontificia Universidad Javeriana, Natura (Brazil) et Universidade Estadual Paulista (Unesp), avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.