Does exogenous glucocorticoid administration during pregnancy precipitate the timing of labor? A scoping review
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Le résumé fourni par la source
Introduction: To investigate whether synthetic (s) glucocorticoids (GCs) administered between the 24th and the 34th gestational weeks in pre-term labor might precipitate labor, studies on sGCs administration were reviewed. The physiology of endogenous glucocorticoid-related increase in fetal-maternal circulation and its association with labor, followed by a scoping review of studies on exogenous sGCs administered for fetal lung maturation and the timing of labor, were included. Materials and methods: The methodology of systematic reviews was followed. MEDLINE, Cochrane Library, and Google Scholar databases were searched until October 2023, for original studies investigating the administration of sGCs in pregnancies risking pre-term labor. Duplicates were removed, and 1867 abstracts were excluded as irrelevant. Six controlled and four non-controlled studies were included. The index group consisted of 6001 subjects and 7691 controls in the former, while in the latter, the index group consisted of 2069 subjects. Results: In three out of the six controlled studies, gestational age at labor was significantly lower in sGC-treated women than in controls, while in three studies, gestational age at labor was lower in sGC-treated women than in controls, with a trend toward statistical significance. In one study, gestational age at labor was significantly lower in controls than in sGC-treated women. In the non-controlled studies, the majority of women delivered less than 1 week from the day of sGC administration. Conclusions: In this scoping review, studies lack homogeneity. However, in the controlled studies, a pattern of earlier labor emerges among sGC-treated pregnant women. The use of multiple courses of antenatal sGCs appears to be associated with precipitated labor. Their use should be carefully weighed. Carefully designed trials should examine this ongoing scientific query.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Does exogenous glucocorticoid administration during pregnancy precipitate the timing of labor? A scoping review
- Date Crossref
- 19/08/2024
- Éditeur
- Bioscientifica
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National and Kapodistrian University of Athens Department of Clinical Therapeutics pays non établi dans la noticeUniversité ou école supérieure
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University General Hospital Attikon pays non établi dans la noticeÉtablissement de santé
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Alexandra Hospital pays non établi dans la noticeÉtablissement de santé
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Aristotle University of Thessaloniki IPPOKRATEIO General Hospital of Thessaloniki pays non établi dans la noticeUniversité ou école supérieure
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Ippokrateio General Hospital of Thessaloniki pays non établi dans la noticeÉtablissement de santé
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University of Ioannina Department of Speech and Language Therapy pays non établi dans la noticeUniversité ou école supérieure
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University of Belgrade pays non établi dans la noticeUniversité ou école supérieure
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Center for Health pays non établi dans la noticeInstitution
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ATTIKON University Hospital Third Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
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ARETAIEION University Hospital Unit of Endocrinology pays non établi dans la noticeUniversité ou école supérieure
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General University Hospital Attikon T Karampitsakos pays non établi dans la noticeUniversité ou école supérieure
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ALEXANDRA University Hospital Unit of Endocrinology pays non établi dans la noticeUniversité ou école supérieure
Department of Clinical Therapeutics — National and Kapodistrian University of Athens, University General Hospital Attikon et Alexandra Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.