Pioneering Research Driving Progress toward a Cure for Interstitial Lung Disease (ILD): Introduction to the AJRCCM Special Issue on ILD (Part 2)

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Pioneering Research Driving Progress toward a Cure for Interstitial Lung Disease (ILD): Introduction to the AJRCCM Special Issue on ILD (Part 2)Welcome to the second American Journal of Respiratory and Critical Care Medicine (AJRCCM) special issue of 2024 dedicated to interstitial lung disease (ILD).Because of the exceptional volume of high-quality submissions from the global ILD community, we are excited to publish two issues this year that focus on these complex conditions.The articles included in this edition highlight new therapeutic strategies, innovative diagnostic tools, and emerging biomarkers that promise to reshape our clinical management of ILD.Additionally, we gain new mechanistic insights that provide a deeper understanding of disease processes and their implications for patient care.We hope that these studies will inspire further research and collaborations in our ongoing effort to improve outcomes for those affected by these challenging diseases.The Spectrum of ILD ILD encompasses a large and heterogenous group of diagnoses, ranging from more inflammatory disorders such as connective tissue disease-associated ILD (CTD-ILD) to intrinsically more fibrotic disease such as idiopathic pulmonary fibrosis (IPF), as described in the Pulmonary Perspective by Behr and colleagues (pp.392-400).The authors detail existing tools to guide clinical decision-making and persistent knowledge gaps in distinguishing each disease process.Adegunsoye and colleagues (pp.401-423) present a state-of-the-art update on recent genetic and genomics advancements in fibrotic ILD and their application to patient care.It is clear from both review articles that better molecular characterization of ILD-including integration of genetic testing, novel biomarkers, advanced imaging algorithms and deeper immune cell profiling-is essential and will allow for more personalized approaches to patient care.

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