A prospective description of HIV-associated multicentric Castleman disease in Malawi

Le résumé fourni par la source

Despite high burden of Kaposi sarcoma (KS) and HIV, multicentric Castleman disease (MCD) is rarely reported in sub-Saharan Africa (SSA). A pathology series in Uganda demonstrated latency-associated nuclear antigen (LANA) and viral interleukin-6 positivity by immunohistochemistry (IHC) in 3 of 64 reactive-appearing lymph nodes, consistent with missed MCD diagnoses,1 but this was before antiretroviral therapy (ART) scale-up when MCD may have been relatively infrequent. In South Africa, a pathology series reported many HIV+ B-cell lymphoproliferations without specifically mentioning MCD.2 A retrospective series from South Africa reported 35 MCD cases during 1990–2014, with most cases in the most recent years within this time period.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.