Effects of exposure to different frequencies of electromagnetic fields on long-term potentiation in rat hippocampal CA1 region through intracellular Ca2+ concentration
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Le résumé fourni par la source
Long-term potentiation (LTP) in the Schaffer-CA1 region of the hippocampus is closely related to learning and memory. Magnetic stimulation, as an effective physical means of regulating synaptic plasticity, has received widespread attention. However, research on the mechanism of the effect of different frequencies of magnetic fields (MFs) on LTP is relatively scarce. This article focuses on Ca2+, Na+, K+, NMDA receptors, and AMPA receptors that play important roles in the process of MF regulation of LTP. A combined electrophysiological and pharmacological approach was used to identify Ca2+ as a key factor in the modulation of LTP by MFs of different frequencies. Subsequently, further experiments revealed that low levels of intracellular Ca2+ concentration ([Ca2+]i) intensified the inhibition of low-frequency MFs on LTP, while high levels of [Ca2+]i enhanced the promotion effect of high-frequency MFs on LTP, indicating a positive correlation between [Ca2+]i levels and MF regulation of LTP levels. The research results of this article may help explore the deeper relationship between different frequencies of MFs and synaptic plasticity, and they also have a certain reference value for magnetic stimulation therapy in the treatment of neurological diseases related to LTP injury or learning and memory deficits.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of exposure to different frequencies of electromagnetic fields on long-term potentiation in rat hippocampal CA1 region through intracellular Ca2+ concentration
- Date Crossref
- 01/08/2024
- Éditeur
- AIP Publishing
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tiangong University pays non établi dans la noticeUniversité ou école supérieure
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Tianjin University Precision Instrument and Opto-Electronics Engineering pays non établi dans la noticeUniversité ou école supérieure
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PLA Army Engineering University pays non établi dans la noticeUniversité ou école supérieure
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School of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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National Key Laboratory Electromagnetic Environmental Effects pays non établi dans la noticeStructure de recherche
Tiangong University, Precision Instrument and Opto-Electronics Engineering — Tianjin University et PLA Army Engineering University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.