An investigation of the glial biomarker myo-Inositol as a marker of brain inflammation in elderly patients with and without delirium.
Le résumé fourni par la source
Myo-Inositol is sometimes considered a marker of brain inflammation and studies indicate mI (mI/tCr) increases with age up to the 6th decade. We performed 1H MRS in four brain regions of very elderly hospitalised patients (n=25, aged 67-90 yrs) of which 12 had delirium. Elevated mI/tCr was associated with increasing Fazekas score for white matter damage (p<0.001) in all regions. In addition mI/tCr and mI/NAA showed negative correlation with age (p<0.001). There were no significant differences between patients with or without delirium. Decreased mI/tCr due to reduced glial cell numbers or dysfunction may coincide with increased mI/tCr associated with inflammation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- An investigation of the glial biomarker myo-Inositol as a marker of brain inflammation in elderly patients with and without delirium.
- Date Crossref
- 14/08/2024
- Éditeur
- ISMRM
- Type
- proceedings-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.