HYPOTHALAMIC VOLUME IS ASSOCIATED WITH BODY MASS INDEX

Résumé fourni par la source

The hypothalamus plays a major role in appetite regulation via well-defined orexigenic and anorexigenic pathways. Perturbation of these pathways is known to alter feeding behaviour and body mass. Using an automated technique, we segmented the hypothalamus in 1299 young adults with variation in body mass index (BMI). We showed that in participants who were overweight or obese, the hypothalamus and constituent nuclei were significantly increased in volume compared to those of a healthy weight. Further, these volume increases are predominantly localised to the arcuate and paraventricular nuclei, which form the core of the neuroendocrine appetite maintenance system.

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