Distinct dACC Glutamate Modulation during Inhibitory Motor Control Driven by Negative Emotional Stimuli in Trauma-Exposed Youth using 1H fMRS

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We investigated changes in glutamate in the dACC in children exposed to childhood trauma during motor control function with and without inhibition as well as with and without stimuli depicting negative affect using 1H fMRS. Independent of motor control with/without inhibition, trauma-exposed children exhibited a significant reduction in dACC glutamate when stimuli of negative affect were present, relative to stimuli without affect. These results provide greater insight on the neurochemistry supporting the influence of negative emotional context on motor control and highlight potential novel biomarkers for risk and resilience to posttraumatic stress.

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