Effect of chemical shift displacement on Lipid Composition determination in localized 1H NMR Spectroscopy

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We showed that implementing prior knowledge about Chemical Shift Displacement Artifacts (CSDA) in localized MR-spectroscopy improves fit quality in the context of hepatic lipid composition measurements (LICO) performed with PRESS. Residuals of fitting PRESS spectra of peanut oil with CSDA prior knowledge show smaller residuals compared to assuming a purely Spin Echo based J-coupling evolution during the echo time. Furthermore, peanut oil LICO measured by PRESS and fitted with CSDA prior knowledge almost matched reference values determined by HR-NMR (PUFAHR-NMR = 23.5%, MUFAHR-NMR = 52.9%, SFAHR-NMR = 23.6% vs. PUFACSDA = 21.57%, MUFACSDA = 54.4%, SFACSDA = 24.0%).

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