Disrupted vein-dominated connectivity and increased CSF involvement in ischemic stroke human brain

Le résumé fourni par la source

High-resolution resting-state (rs) fMRI enables the functional mapping of vein-dominated connectivity, correlated with neuronal calcium signals. Here, we performed high-resolution rs-fMRI to examine 30 ischemic stroke patients with binocular isotropic hemianopia and 10 healthy controls. The results of seed-based and independent component analysis (ICA) demonstrated the reduced vein-dominated correlation patterns. Interestingly, ICA also found increased correlations between cerebrospinal fluid (CSF) and ischemic lesions in stroke patients, showing ultra-slow oscillation frequencies up to 0.04 Hz. Our findings suggest that ischemic lesions are associated with CSF, prompting disruption of vein-dominated connectivity.

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