Multimodality detection of tumour rupture in children with Wilms tumour
Rattachement africain : gb, qa, dk, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND AND AIMS: Tumour rupture (TR) signifies stage III disease and requires treatment intensification, which includes radiotherapy. We studied the associations between radiological, surgical and pathology TR in children with Wilms tumour (WT) in a United Kingdom multicentre clinical study. PATIENTS AND METHODS: The IMPORT (Improving Population Outcomes for Renal Tumours of Childhood) study registered 712 patients between 2012 and 2021. Children with TR on central radiology review (CRR) at diagnosis and/or indication of preoperative TR on surgical forms were included. Correlation between radiology/surgery/pathology findings was made. RESULTS: Total 141 patients had TR identified (69 on CRR, 43 on surgical form and 29 on both), and 124/141 had images available for CRR, and 98/124 had features suggestive of TR on diagnostic CRR (63 magnetic resonance imaging/35 computed tomography). TR was limited to the renal fossa in 47/98 (48%) and intraperitoneal in 51/98 (52%). Three of 98(3%) had upfront surgery, and 87/95 (92%) had TR confirmed on post-chemotherapy preoperative scans. Among 80/98 (82%) cases with TR on CRR and available surgical forms, TR was not confirmed on surgery or pathology in 38/80, giving a false-positive rate of 48%. Preoperative TR was indicated on 72 surgical forms, with images available for CRR in 55. Twenty-six of 55 (47%) were false-negative for TR on CRR and of those 10/26 (38%) had TR confirmed on pathology. CONCLUSIONS: Radiology alone should not be used to define TR, as it does not accurately correlate with surgical or pathology findings, and therefore cannot be relied upon for definitive staging and treatment. A multidisciplinary team should take the decision regarding the final abdominal stage and treatment using a multimodality approach considering clinical, radiological, surgical and pathological findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multimodality detection of tumour rupture in children with Wilms tumour
- Date Crossref
- 08/08/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Great Ormond Street Hospital Department of Paediatric Urology pays non établi dans la noticeÉtablissement de santé
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Great Ormond Street Hospital for Children NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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University College London Developmental Biology and Cancer Department pays non établi dans la noticeUniversité ou école supérieure
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Manchester University NHS Foundation Trust Department of Paediatric Oncology pays non établi dans la noticeÉtablissement de santé
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Leeds Teaching Hospitals NHS Trust Department of Paediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Qatar Airways (Qatar) pays non établi dans la noticeEntreprise
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The Christie NHS Foundation Trust pays non établi dans la noticeOrganisme public
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Rigshospitalet Department of Paediatric Oncology and Haematology pays non établi dans la noticeÉtablissement de santé
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Sorbonne Université pays non établi dans la noticeUniversité ou école supérieure
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Hôpital Armand-Trousseau pays non établi dans la noticeÉtablissement de santé
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Assistance Publique – Hôpitaux de Paris pays non établi dans la noticeÉtablissement de santé
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Genomics (United Kingdom) pays non établi dans la noticeEntreprise
Department of Paediatric Urology — Great Ormond Street Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust et Developmental Biology and Cancer Department — University College London, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.