The Impact of Grape Juice Extract on Liver Structure of Castrated Rats

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The effects of ingestion of freshly prepared ethanolic extracts of 6g/kg/day of black grape juice was investigated on some biochemical, parameters and histological structure of liver in castrated male rats for 42 days. Twenty-one male rats (Rattus norvegicus) were used in the present study. Rats are divided into three groups of animals (N= 7). Tap water was given to the intact and castrated rats in groups 1 and 2. Daily, 1 ml (6g/kg/day) of grape extract was administered intragastrically to the castrated rats in group three. The biochemical test for several parameters did not reveal any differences between the groups that were being compared. Whereas the values of HDL showed a significant difference in both castrated and castrated treated subjects as compared with control animals (P<0.01; P<0.05) respectively, as well as the results of VLDL showed a significant difference in castrated treated group (P< 0.02). However, the value of ALP also showed a significant difference in castrated treated group (P<0.03). Castration had a major impact on the histological structure of the liver, resulting in lobular inflammation, ballooning degeneration, and macrovesicular steatoses. The liver structure of castrated rats was found to be improved effectively by grape juice treatment, as indicated by histological sections showing a moderate normal architecture to some extent. Administration of grape extract was significantly affecting the histological regeneration of the liver in castrated rats. Keywords: liver; castration; grape juice; central vein.